High pretransplant FGF23 level is associated with persistent vitamin D insufficiency and poor graft survival in kidney transplant patients
DC Field | Value | Language |
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dc.contributor.author | Ryu, Jung-Hwa | - |
dc.contributor.author | Jeon, Hee Jung | - |
dc.contributor.author | Ro, Han | - |
dc.contributor.author | Jung, Hee-Yeon | - |
dc.contributor.author | Kim, Myung-Gyu | - |
dc.contributor.author | Huh, Kyu Ha | - |
dc.contributor.author | Park, Jae Berm | - |
dc.contributor.author | Kang, Kyung Pyo | - |
dc.contributor.author | Han, Seungyeup | - |
dc.contributor.author | Yang, Jaeseok | - |
dc.date.accessioned | 2024-02-09T16:30:19Z | - |
dc.date.available | 2024-02-09T16:30:19Z | - |
dc.date.issued | 2023-11 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/90359 | - |
dc.description.abstract | Vitamin D-3 (25[OH]D-3) insufficiency and fibroblast growth factor 23 (FGF23) elevation are usually attenuated after kidney transplantation (KT). However, elevated FGF23 may be associated with poor graft outcomes and vitamin D insufficiency after KT. This study investigated the effect of pretransplant FGF23 levels on post-KT 25(OH)D-3 status and graft outcomes. Serum FGF23 levels from 400 participants of the KoreaN Cohort Study for Outcome in Patients With Kidney Transplantation were measured. Annual serum 25(OH)D-3 levels, all-cause mortality, cardiovascular event, and graft survival were assessed according to baseline FGF23 levels. Serum 25(OH)D-3 levels were initially increased 1 year after KT (12.6 +/- 7.4 vs. 22.6 +/- 6.4 ng/mL). However, the prevalence of post-KT vitamin D deficiency increased again after post-KT 3 years (79.1% at baseline, 30.8% and 37.8% at 3 and 6 years, respectively). Serum FGF23 level was decreased 3 years post-KT. When participants were categorized into tertiles according to baseline FGF23 level (low, middle, high), 25(OH)D-3 level in the low FGF23 group was persistently low at a median follow-up of 8.3 years. Furthermore, high baseline FGF23 level was a risk factor for poor graft survival (HR 5.882, 95% C.I.; 1.443-23.976, P=0.013). Elevated FGF23 levels are associated with persistently low post-transplant vitamin D levels and poor graft survival. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | NATURE PORTFOLIO | - |
dc.title | High pretransplant FGF23 level is associated with persistent vitamin D insufficiency and poor graft survival in kidney transplant patients | - |
dc.type | Article | - |
dc.identifier.wosid | 001136497000080 | - |
dc.identifier.doi | 10.1038/s41598-023-46889-0 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.13, no.1 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85176259380 | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 13 | - |
dc.citation.number | 1 | - |
dc.type.docType | Article | - |
dc.publisher.location | 독일 | - |
dc.subject.keywordPlus | GROWTH-FACTOR 23 | - |
dc.subject.keywordPlus | LEFT-VENTRICULAR HYPERTROPHY | - |
dc.subject.keywordPlus | CARDIOVASCULAR EVENTS | - |
dc.subject.keywordPlus | POSTTRANSPLANT HYPOPHOSPHATEMIA | - |
dc.subject.keywordPlus | MINERAL METABOLISM | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | FGF-23 | - |
dc.subject.keywordPlus | PHOSPHORUS | - |
dc.subject.keywordPlus | FACTOR-23 | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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