Microglial STING activation alleviates nerve injury-induced neuropathic pain in male but not female miceopen access
- Authors
- Prudente, Arthur Silveira; Lee, Sang Hoon; Roh, Jueun; Luckemeyer, Debora D.; Cohen, Cinder F.; Pertin, Marie; Park, Chul-Kyu; Suter, Marc R.; Decosterd, Isabelle; Zhang, Jun -Ming; Ji, Ru-Rong; Berta, Temugin
- Issue Date
- Mar-2024
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- Neuropathic pain; Microglia; STING; Spared nerve injury; Sex difference; Interferon; Cytokines
- Citation
- BRAIN BEHAVIOR AND IMMUNITY, v.117, pp 51 - 65
- Pages
- 15
- Journal Title
- BRAIN BEHAVIOR AND IMMUNITY
- Volume
- 117
- Start Page
- 51
- End Page
- 65
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/90509
- DOI
- 10.1016/j.bbi.2024.01.003
- ISSN
- 0889-1591
1090-2139
- Abstract
- Microglia, resident immune cells in the central nervous system, play a role in neuroinflammation and the development of neuropathic pain. We found that the stimulator of interferon genes (STING) is predominantly expressed in spinal microglia and upregulated after peripheral nerve injury. However, mechanical allodynia, as a marker of neuropathic pain following peripheral nerve injury, did not require microglial STING expression. In contrast, STING activation by specific agonists (ADU-S100, 35 nmol) significantly alleviated neuropathic pain in male mice, but not female mice. STING activation in female mice leads to increase in proinflammatory cytokines that may counteract the analgesic effect of ADU-S100. Microglial STING expression and type I interferon-ss (IFNss) signaling were required for the analgesic effects of STING agonists in male mice. Mechanistically, downstream activation of TANK-binding kinase 1 (TBK1) and the production of IFN-ss, may partly account for the analgesic effect observed. These findings suggest that STING activation in spinal microglia could be a potential therapeutic intervention for neuropathic pain, particularly in males.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - ETC > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/90509)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.