Clinical Significance of Physical Frailty in Subjects With Subjective Cognitive Decline: A Prospective Study With Amyloid PET Data
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lim, Eun Ye | - |
dc.contributor.author | Ho, Seong Hee | - |
dc.contributor.author | Hong, Yun Jeong | - |
dc.contributor.author | Jeong, Jee Hyang | - |
dc.contributor.author | Park, Hee Kyung | - |
dc.contributor.author | Park, Kee Hyung | - |
dc.contributor.author | Kim, Sang Yun | - |
dc.contributor.author | Wang, Min Jeong | - |
dc.contributor.author | Choi, Seong Hye | - |
dc.contributor.author | Shim, Yong Soo | - |
dc.contributor.author | Cho, A. Hyun | - |
dc.contributor.author | Yang, Dong Won | - |
dc.date.accessioned | 2024-03-06T11:30:29Z | - |
dc.date.available | 2024-03-06T11:30:29Z | - |
dc.date.issued | 2023-09 | - |
dc.identifier.issn | 1738-6586 | - |
dc.identifier.issn | 2005-5013 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/90548 | - |
dc.description.abstract | Background and Purpose Physical frailty is known to be closely associated with cognitive impairment and to be an early sign of Alzheimer's disease. We aimed to understand the characteristics of physical frailty and define factors associated with physical frailty in subjects with subjective cognitive decline (SCD) by analyzing amyloid data. Methods We prospectively enrolled subjects with SCD from a cohort study to identify predictors for the clinical progression to mild cognitive impairment or dementia from SCD (CoSCo). All of the subjects underwent brain magnetic resonance imaging, and brain amyloid positron-emission tomography (PET) to detect amyloid beta plaques. Self-reported exhaustion, handgrip strength, and gait speed were used to measure physical frailty. Results Of 120 subjects with SCD, 26 (21.7%) were amyloid-positive in PET. Female (odds ratio [OR]=3.79, p=0.002) and amyloid-PET-positive (OR=3.80, p=0.008) subjects with SCD were at high risks of self-reported exhaustion. Amyloid PET positivity (OR=3.22, p=0.047) and high burden from periventricular white-matter hyperintensity (OR=3.34, 95% confidence interval=1.18-9.46, p=0.023) were significantly associated with a weaker handgrip. The subjects with SCD with self-reported exhaustion and weaker handgrip presented with lower cognitive performance in neuropsychological tests, especially for information processing speed and executive function. Subjects with a slower gait performed worse in visual memory function tests. Conclusions Amyloid PET positivity was associated with a higher risk of self-reported exhaustion and weaker handgrip in subjects with SCD. The subjects with SCD and physical frailty also performed worse in neuropsychological tests. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN NEUROLOGICAL ASSOC | - |
dc.title | Clinical Significance of Physical Frailty in Subjects With Subjective Cognitive Decline: A Prospective Study With Amyloid PET Data | - |
dc.type | Article | - |
dc.identifier.wosid | 001158928600001 | - |
dc.identifier.doi | 10.3988/jcn.2022.0353 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL NEUROLOGY, v.19, no.5, pp 447 - 453 | - |
dc.identifier.kciid | ART002987047 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85169790955 | - |
dc.citation.endPage | 453 | - |
dc.citation.startPage | 447 | - |
dc.citation.title | JOURNAL OF CLINICAL NEUROLOGY | - |
dc.citation.volume | 19 | - |
dc.citation.number | 5 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | physical frailty | - |
dc.subject.keywordAuthor | subjective cognitive decline | - |
dc.subject.keywordAuthor | Alzheimer's disease | - |
dc.subject.keywordAuthor | amyloid positron emission tomography computed tomography | - |
dc.subject.keywordPlus | VASCULAR DEMENTIA | - |
dc.subject.keywordPlus | SEX-DIFFERENCES | - |
dc.subject.keywordPlus | OLDER-ADULTS | - |
dc.subject.keywordPlus | FATIGUE | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | IMPAIRMENT | - |
dc.subject.keywordPlus | SARCOPENIA | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.