Quantitative interstitial lung disease scores in idiopathic inflammatory myopathies: longitudinal changes and clinical implications
DC Field | Value | Language |
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dc.contributor.author | Yeo, Jina | - |
dc.contributor.author | Yoon, Soon Ho | - |
dc.contributor.author | Kim, Ju Yeon | - |
dc.contributor.author | Lee, Jeong Seok | - |
dc.contributor.author | Lee, Eun Young | - |
dc.contributor.author | Goo, Jin Mo | - |
dc.contributor.author | Pourzand, Lila | - |
dc.contributor.author | Goldin, Jonathan G. | - |
dc.contributor.author | Kim, Grace-Hyun J. | - |
dc.contributor.author | Ha, You-Jung | - |
dc.date.accessioned | 2024-03-09T10:30:25Z | - |
dc.date.available | 2024-03-09T10:30:25Z | - |
dc.date.issued | 2023-11 | - |
dc.identifier.issn | 1462-0324 | - |
dc.identifier.issn | 1462-0332 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/90598 | - |
dc.description.abstract | Objectives To investigate computer-aided quantitative scores from high-resolution CT (HRCT) images and determine their longitudinal changes and clinical significance in patients with idiopathic inflammatory myopathies (IIMs)-related interstitial lung disease (IIMs-ILD). Methods The clinical data and HRCT images of 80 patients with IIMs who underwent serial HRCT scans at least twice were retrospectively analysed. Quantitative ILD (QILD) scores (%) were calculated as the sum of the extent of lung fibrosis, ground-glass opacity, and honeycombing. The individual time-estimated Delta QILD between two consecutive scans was derived using a linear approximation of yearly changes. Results The baseline median QILD (interquartile range) scores in the whole lung were 28.1% (19.1-43.8). The QILD was significantly correlated with forced vital capacity (r = -0.349, P = 0.002) and diffusing capacity for carbon monoxide (r = -0.381, P = 0.001). For Delta QILD between the first two scans, according to the visual ILD subtype, QILD aggravation was more frequent in patients with usual interstitial pneumonia (UIP) than non-UIP (80.0% vs 44.4%, P = 0.013). Multivariable logistic regression analyses identified UIP was significantly related to radiographic ILD progression (Delta QILD >2%, P = 0.015). Patients with higher baseline QILD scores (>28.1%) had a higher risk of lung transplantation or death (P = 0.015). In the analysis of three serial HRCT scans (n = 41), dynamic Delta QILD with four distinct patterns (improving, worsening, convex and concave) was observed. Conclusion QILD changes in IIMs-ILD were dynamic, and baseline UIP patterns seemed to be related to a longitudinal progression in QILD. These may be potential imaging biomarkers for lung function, changes in ILD severity and prognosis in IIMs-ILD. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.title | Quantitative interstitial lung disease scores in idiopathic inflammatory myopathies: longitudinal changes and clinical implications | - |
dc.type | Article | - |
dc.identifier.wosid | 000951731900001 | - |
dc.identifier.doi | 10.1093/rheumatology/kead122 | - |
dc.identifier.bibliographicCitation | RHEUMATOLOGY, v.62, no.11, pp 3690 - 3699 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85176509058 | - |
dc.citation.endPage | 3699 | - |
dc.citation.startPage | 3690 | - |
dc.citation.title | RHEUMATOLOGY | - |
dc.citation.volume | 62 | - |
dc.citation.number | 11 | - |
dc.type.docType | Article; Early Access | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | idiopathic inflammatory myopathy | - |
dc.subject.keywordAuthor | interstitial lung disease | - |
dc.subject.keywordAuthor | lung transplant-free survival | - |
dc.subject.keywordAuthor | quantitative score | - |
dc.subject.keywordPlus | SCLERODERMA | - |
dc.subject.keywordPlus | CLASSIFICATION | - |
dc.subject.keywordPlus | QUANTIFICATION | - |
dc.subject.keywordPlus | POLYMYOSITIS | - |
dc.subject.keywordPlus | PATTERNS | - |
dc.subject.keywordPlus | FIBROSIS | - |
dc.subject.keywordPlus | MYOSITIS | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | EXTENT | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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