Synthesis of Multicolor Fluorescent N-Doped Carbon Dots for Bioimaging Applications
- Authors
- Lee, Hak Hyeon; Kim, Jong Sung
- Issue Date
- Dec-2023
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- bioimaging; multicolor emission; N-doped carbon dots
- Citation
- PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE, v.220, no.24
- Journal Title
- PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE
- Volume
- 220
- Number
- 24
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/90602
- DOI
- 10.1002/pssa.202300216
- ISSN
- 1862-6300
1862-6319
- Abstract
- Carbon dots (CDs) are attracting significant research attention due to their low toxicity and highly favorable photochemical properties. This study reports the synthesis of nitrogen-doped CDs (N-CDs) using 3-aminophenol and o-phenylenediamine as carbon precursors and their application to nontoxic, biocompatible polychromatic agents for biological imaging studies. The prepared N-CDs exhibit multicolored fluorescence (blue, green, yellow, orange) with excellent optical stability and biocompatibility. As a result of Fourier-transform infrared spectroscopy and X-ray photoelectron spectroscopy, N-CD is found to have similar -OH and C-H in the surface functional group, showing a graphene structure with good hydrophilicity. The size of the synthesized N-CDs is confirmed by transmission electron microscopy images to be less than 10 nm. The 3-4,5-dimethylthiazol-2,5-diphenyl tetrazolium bromide analysis is performed using HeLa cells, and cell survival is very high in all N-CDs. Among N-CDs, G-CDs exhibit the highest fluorescence intensity and provide excellent fluorescence microscopic images for cells in blue, green, and red channels.
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