Molecular weight-dependent effects of Undaria pinnatifida fucoidan isolates on palmitate-induced inflammation and muscle atrophy in C2C12 myotubes
- Authors
- Kim, Jong-Yeon; Park, Eun-Jung; Lee, Hae-Jeung
- Issue Date
- Feb-2024
- Publisher
- SPRINGER
- Keywords
- Fucoidan; Molecular weight; Obesity; Inflammation; Skeletal muscle atrophy
- Citation
- JOURNAL OF APPLIED PHYCOLOGY, v.36, no.1, pp 411 - 419
- Pages
- 9
- Journal Title
- JOURNAL OF APPLIED PHYCOLOGY
- Volume
- 36
- Number
- 1
- Start Page
- 411
- End Page
- 419
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/90608
- DOI
- 10.1007/s10811-023-03111-y
- ISSN
- 0921-8971
1573-5176
- Abstract
- Obesity is consistently linked to skeletal muscle atrophy. It is characterized by a chronic inflammatory state that produces various pro-inflammatory substances that may have negative effects on muscles, such as muscle atrophy, impaired muscle regeneration, and a reduction in muscle protein synthesis. Fucoidan, isolated from the brown alga Undaria pinnatifida, is composed of fucose, galactose, and sulfate groups, and is known to have anti-obesity, anti-tumor, and immunomodulatory properties. Recent studies have indicated that the bioactivity of fucoidans depends on their molecular weight; however, this correlation remains unclear and requires further investigation. This study aimed to evaluate and compare the effects of three different fucoidans, based on their molecular weight, on palmitate (PA)-induced muscle atrophy using C2C12 myotubes. The fucoidan types were low molecular weight fucoidan (LMWF, >= 30 kDa), medium molecular weight fucoidan (MMWF, >= 110 kDa), and high molecular weight fucoidan (HMWF, >= 200 kDa). Our results demonstrate that all fucoidans reduced lipid accumulation. Additionally, all three fucoidans reduced tumor necrosis factor-alpha (TNF-alpha) mRNA expression level in PA-induced inflammation, whereas interleukin-1beta (IL-1 beta) and IL-6 mRNA expression levels were reduced only in the HMWF-treated group. Moreover, MMWF and HMWF significantly reduced the mRNA expression levels of the muscle atrophy genes muscle RING-finger protein-1 (MuRF1) and Atrogin-1, while LMWF showed no significant effects. In conclusion, HMWF showed more promising outcomes than LMWF and MMWF, suggesting its potential as a therapeutic agent for the treatment of obesity-induced inflammation and muscle atrophy.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - ETC > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/90608)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.