Ameliorative Effects of Zingiber officinale Rosc on Antibiotic-Associated Diarrhea and Improvement in Intestinal Function
DC Field | Value | Language |
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dc.contributor.author | Kim, Sung Jin | - |
dc.contributor.author | Shin, Myoung-Sook | - |
dc.contributor.author | Choi, You-Kyung | - |
dc.date.accessioned | 2024-03-12T12:30:56Z | - |
dc.date.available | 2024-03-12T12:30:56Z | - |
dc.date.issued | 2024-02 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/90642 | - |
dc.description.abstract | The global increase in antibiotic consumption is related to increased adverse effects, such as antibiotic-associated diarrhea (AAD). This study investigated the chemical properties of Zingiber officinale Rosc (ZO) extract and its ameliorative effects using a lincomycin-induced AAD mouse model. Intestinal tissues were evaluated for the expression of lysozyme, claudin-1, and alpha-defensin-1, which are associated with intestinal homeostasis. The cecum was analyzed to assess the concentration of short-chain fatty acids (SCFAs). The chemical properties analysis of ZO extracts revealed the levels of total neutral sugars, acidic sugars, proteins, and polyphenols to be 86.4%, 8.8%, 4.0%, and 0.8%, respectively. Furthermore, the monosaccharide composition of ZO was determined to include glucose (97.3%) and galactose (2.7%). ZO extract administration ameliorated the impact of AAD and associated weight loss, and water intake also returned to normal. Moreover, treatment with ZO extract restored the expression levels of lysozyme, alpha-defensin-1, and claudin-1 to normal levels. The decreased SCFA levels due to induced AAD showed a return to normal levels. The results indicate that ZO extract improved AAD, strengthened the intestinal barrier, and normalized SCFA levels, showing that ZO extract possesses intestinal-function strengthening effects. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI | - |
dc.title | Ameliorative Effects of Zingiber officinale Rosc on Antibiotic-Associated Diarrhea and Improvement in Intestinal Function | - |
dc.type | Article | - |
dc.identifier.wosid | 001161080500001 | - |
dc.identifier.doi | 10.3390/molecules29030732 | - |
dc.identifier.bibliographicCitation | MOLECULES, v.29, no.3 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85184722141 | - |
dc.citation.title | MOLECULES | - |
dc.citation.volume | 29 | - |
dc.citation.number | 3 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | antibiotic-associated diarrhea | - |
dc.subject.keywordAuthor | intestinal barrier | - |
dc.subject.keywordAuthor | short-chain fatty acid | - |
dc.subject.keywordAuthor | Zingiber officinale Roscoe | - |
dc.subject.keywordPlus | BARRIER FUNCTION | - |
dc.subject.keywordPlus | GUT MICROBIOTA | - |
dc.subject.keywordPlus | GINGER | - |
dc.subject.keywordPlus | HEALTH | - |
dc.subject.keywordPlus | MODULATION | - |
dc.subject.keywordPlus | ALLEVIATION | - |
dc.subject.keywordPlus | SUPPRESSION | - |
dc.subject.keywordPlus | PROBIOTICS | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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