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Circulating osteoprotegerin levels and cardiovascular outcomes in patients with pre-dialysis chronic kidney disease: results from the KNOW-CKD study

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dc.contributor.authorSuh, Sang Heon-
dc.contributor.authorOh, Tae Ryom-
dc.contributor.authorChoi, Hong Sang-
dc.contributor.authorKim, Chang Seong-
dc.contributor.authorBae, Eun Hui-
dc.contributor.authorMa, Seong Kwon-
dc.contributor.authorOh, Kook-Hwan-
dc.contributor.authorLee, Kyu-Beck-
dc.contributor.authorJeong, Jong Cheol-
dc.contributor.authorJung, Ji Yong-
dc.contributor.authorKim, Soo Wan-
dc.date.accessioned2024-03-21T11:00:15Z-
dc.date.available2024-03-21T11:00:15Z-
dc.date.issued2024-02-
dc.identifier.issn2045-2322-
dc.identifier.urihttps://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/90774-
dc.description.abstractWhile the relationship between circulating osteoprotegerin (OPG) and cardiovascular events is well-established in the general population, its association with cardiovascular risks in chronic kidney disease (CKD) patients remains less robust. This study hypothesized that elevated circulating OPG levels might be associated with an increased risk of major adverse cardiac events (MACE) in CKD patients, a total of 2,109 patients with CKD stages 1 through pre-dialysis 5 from the KNOW-CKD cohort were categorized into quartiles based on serum OPG levels. The primary outcome of the study was 3-point MACE, defined as a composite of nonfatal myocardial infarction, nonfatal stroke, or cardiac death. The median follow-up duration was 7.9 years. The cumulative incidence of 3-point MACE significantly varied across serum OPG levels in Kaplan-Meier curve analysis (P < 0.001, log-rank test), with the highest incidence observed in the 4th quartile. Cox regression analysis indicated that, relative to the 1st quartile, the risk of 3-point MACE was significantly higher in the 3rd (adjusted hazard ratio 2.901, 95% confidence interval 1.009 to 8.341) and the 4th quartiles (adjusted hazard ratio 4.347, 95% confidence interval 1.410 to 13.395). In conclusion, elevated circulating OPG levels are associated with adverse cardiovascular outcomes in pre-dialysis CKD patients.-
dc.language영어-
dc.language.isoENG-
dc.publisherNATURE PORTFOLIO-
dc.titleCirculating osteoprotegerin levels and cardiovascular outcomes in patients with pre-dialysis chronic kidney disease: results from the KNOW-CKD study-
dc.typeArticle-
dc.identifier.wosid001167137100069-
dc.identifier.doi10.1038/s41598-024-54335-y-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, v.14, no.1-
dc.description.isOpenAccessY-
dc.identifier.scopusid2-s2.0-85185477726-
dc.citation.titleSCIENTIFIC REPORTS-
dc.citation.volume14-
dc.citation.number1-
dc.type.docTypeArticle-
dc.publisher.location독일-
dc.subject.keywordAuthorBiomarker-
dc.subject.keywordAuthorChronic kidney disease-
dc.subject.keywordAuthorMajor adverse cardiac event-
dc.subject.keywordAuthorOsteoprotegerin-
dc.subject.keywordPlusCORONARY-ARTERY CALCIFICATION-
dc.subject.keywordPlusSERUM OSTEOPROTEGERIN-
dc.subject.keywordPlusHEART-FAILURE-
dc.subject.keywordPlusPLASMA OSTEOPROTEGERIN-
dc.subject.keywordPlusRISK-
dc.subject.keywordPlusMORTALITY-
dc.subject.keywordPlusEVENTS-
dc.subject.keywordPlusBIOMARKERS-
dc.subject.keywordPlusBONE-
dc.subject.keywordPlusASSOCIATION-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.relation.journalWebOfScienceCategoryMultidisciplinary Sciences-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
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