Differences in Clinical Outcomes Between Hydroxyurea-Resistant and-Intolerant Polycythemia Vera Patients
DC Field | Value | Language |
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dc.contributor.author | Lee, Sung-Eun | - |
dc.contributor.author | Hong, Junshik | - |
dc.contributor.author | Bang, Soo-Mee | - |
dc.contributor.author | Park, Jinny | - |
dc.contributor.author | Choi, Chul Won | - |
dc.contributor.author | Bae, Sung Hwa | - |
dc.contributor.author | Kim, Min Kyoung | - |
dc.contributor.author | Yoon, Seug Yun | - |
dc.contributor.author | Kim, Sung-Yong | - |
dc.date.accessioned | 2024-04-12T00:00:48Z | - |
dc.date.available | 2024-04-12T00:00:48Z | - |
dc.date.issued | 2024-01 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.issn | 1598-6357 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/90962 | - |
dc.description.abstract | Background: Previous studies have suggested that patients with polycythemia vera (PV) who exhibit hydroxyurea-resistance (HU-R) and-intolerance (HU-I) may have distinct characteristics and clinical outcomes. However, to date, no studies have reported a comparison between these two groups or assessed prognostic factors in these patients. Methods: The objective of this study was to evaluate clinical outcomes and identify prognostic factors among PV patients with HU-R or HU-I. We conducted a review of PV patients who received frontline treatment with HU from nine centers and identified 90 patients with HU-R or HU-I. Results: The cumulative incidence of thrombosis after 7 years of HU-R/I was 21.4%, and the incidence of disease progression was 22.5%. Comparing the HU-R and HU-I groups, the HU-R group had a significantly higher rate of disease progression (36.7% vs. 0.56%, P = 0.009), while there was no significant difference in thrombosis incidence (19.0% vs. 22.9%, P = 0.463). Multivariate analysis revealed that HU-R was an independent prognostic factor for progression-free survival (hazard ratio, 6.27, 95% confidence interval, 1.83-21.47, P = 0.003). Additionally, higher lactate dehydrogenase levels, multiple cardiovascular risk factors, and prior thrombosis were identified as unfavorable predictors of overall survival. Conclusion: These findings suggest that patients with HU-R face a higher risk of hematological transformation, but have a comparable risk of thrombosis to patients with HU intolerance. These distinctions should guide decisions on second-line treatment options and clinical trials involving these patients. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | - |
dc.title | Differences in Clinical Outcomes Between Hydroxyurea-Resistant and-Intolerant Polycythemia Vera Patients | - |
dc.type | Article | - |
dc.identifier.wosid | 001165994500006 | - |
dc.identifier.doi | 10.3346/jkms.2024.39.e24 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, v.39, no.3, pp 1 - 10 | - |
dc.identifier.kciid | ART003046026 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85183286697 | - |
dc.citation.endPage | 10 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.volume | 39 | - |
dc.citation.number | 3 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Polycythemia Vera | - |
dc.subject.keywordAuthor | Hydroxyurea | - |
dc.subject.keywordAuthor | Drug Resistance | - |
dc.subject.keywordAuthor | Intolerance | - |
dc.subject.keywordPlus | PROGNOSTIC VALUE | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | HYDROXYCARBAMIDE | - |
dc.subject.keywordPlus | MYELOFIBROSIS | - |
dc.subject.keywordPlus | RUXOLITINIB | - |
dc.subject.keywordPlus | DEFINITION | - |
dc.subject.keywordPlus | NEOPLASMS | - |
dc.subject.keywordPlus | THERAPY | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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