Characteristics of discordance between amyloid positron emission tomography and plasma amyloid-β 42/40 positivity
DC Field | Value | Language |
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dc.contributor.author | Pyun, Jung-Min | - |
dc.contributor.author | Park, Young Ho | - |
dc.contributor.author | Youn, Young Chul | - |
dc.contributor.author | Kang, Min Ju | - |
dc.contributor.author | Shim, Kyu Hwan | - |
dc.contributor.author | Jang, Jae-Won | - |
dc.contributor.author | You, Jihwan | - |
dc.contributor.author | Nho, Kwangsik | - |
dc.contributor.author | Kim, SangYun | - |
dc.date.accessioned | 2024-05-02T13:30:19Z | - |
dc.date.available | 2024-05-02T13:30:19Z | - |
dc.date.issued | 2024-02 | - |
dc.identifier.issn | 2158-3188 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/91082 | - |
dc.description.abstract | Various plasma biomarkers for amyloid-beta (A beta) have shown high predictability of amyloid PET positivity. However, the characteristics of discordance between amyloid PET and plasma A beta 42/40 positivity are poorly understood. Thorough interpretation of discordant cases is vital as A beta plasma biomarker is imminent to integrate into clinical guidelines. We aimed to determine the characteristics of discordant groups between amyloid PET and plasma A beta 42/40 positivity, and inter-assays variability depending on plasma assays. We compared tau burden measured by PET, brain volume assessed by MRI, cross-sectional cognitive function, longitudinal cognitive decline and polygenic risk score (PRS) between PET/plasma groups (PET-/plasma-, PET-/plasma+, PET+/plasma-, PET+/plasma+) using Alzheimer's Disease Neuroimaging Initiative database. Additionally, we investigated inter-assays variability between immunoprecipitation followed by mass spectrometry method developed at Washington University (IP-MS-WashU) and Elecsys immunoassay from Roche (IA-Elc). PET+/plasma+ was significantly associated with higher tau burden assessed by PET in entorhinal, Braak III/IV, and Braak V/VI regions, and with decreased volume of hippocampal and precuneus regions compared to PET-/plasma-. PET+/plasma+ showed poor performances in global cognition, memory, executive and daily-life function, and rapid cognitive decline. PET+/plasma+ was related to high PRS. The PET-/plasma+ showed intermediate changes between PET-/plasma- and PET+/plasma+ in terms of tau burden, hippocampal and precuneus volume, cross-sectional and longitudinal cognition, and PRS. PET+/plasma- represented heterogeneous characteristics with most prominent variability depending on plasma assays. Moreover, IP-MS-WashU showed more linear association between amyloid PET standardized uptake value ratio and plasma A beta 42/40 than IA-Elc. IA-Elc showed more plasma A beta 42/40 positivity in the amyloid PET-negative stage than IP-MS-WashU. Characteristics of PET-/plasma+ support plasma biomarkers as early biomarker of amyloidopathy prior to amyloid PET. Various plasma biomarker assays might be applied distinctively to detect different target subjects or disease stages. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SPRINGERNATURE | - |
dc.title | Characteristics of discordance between amyloid positron emission tomography and plasma amyloid-β 42/40 positivity | - |
dc.type | Article | - |
dc.identifier.wosid | 001160268700002 | - |
dc.identifier.doi | 10.1038/s41398-024-02766-6 | - |
dc.identifier.bibliographicCitation | TRANSLATIONAL PSYCHIATRY, v.14, no.1 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85184789159 | - |
dc.citation.title | TRANSLATIONAL PSYCHIATRY | - |
dc.citation.volume | 14 | - |
dc.citation.number | 1 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | COMPOSITE SCORE | - |
dc.subject.keywordPlus | DEMENTIA | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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