Risk of Severe COVID-19 and Protective Effectiveness of Vaccination Among Solid Organ Transplant Recipients
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Huh, Kyungmin | - |
dc.contributor.author | Kang, Minsun | - |
dc.contributor.author | Kim, Young-Eun | - |
dc.contributor.author | Choi, Yoonkyung | - |
dc.contributor.author | An, Soo Jeong | - |
dc.contributor.author | Seong, Jaehyun | - |
dc.contributor.author | Go, Min Jin | - |
dc.contributor.author | Kang, Ji-Man | - |
dc.contributor.author | Jung, Jaehun | - |
dc.date.accessioned | 2024-05-05T11:30:20Z | - |
dc.date.available | 2024-05-05T11:30:20Z | - |
dc.date.issued | 2024-04 | - |
dc.identifier.issn | 0022-1899 | - |
dc.identifier.issn | 1537-6613 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/91114 | - |
dc.description.abstract | Background Solid organ transplant recipients (SOTRs) are at higher risk for severe infection. However, the risk for severe COVID-19 and vaccine effectiveness among SOTRs remain unclear.Methods This retrospective study used a nationwide health care claims database and COVID-19 registry from the Republic of Korea (2020 to 2022). Adult SOTRs diagnosed with COVID-19 were matched with up to 4 non-SOTR COVID-19 patients by propensity score. Severe COVID-19 was defined as treatment with high-flow nasal cannulae, mechanical ventilation, or extracorporeal membrane oxygenation.Results Among 6783 SOTRs with COVID-19, severe COVID-19 was reported with the highest rate in lung transplant recipients (13.16%), followed by the heart (6.30%), kidney (3.90%), and liver (2.40%). SOTRs had a higher risk of severe COVID-19 compared to non-SOTRs, and lung transplant recipients showed the highest risk (adjusted odds ratio, 18.14; 95% confidence interval [CI], 8.53-38.58). Vaccine effectiveness against severe disease among SOTRs was 47% (95% CI, 18%-65%), 64% (95% CI, 49%-75%), and 64% (95% CI, 29%-81%) for 2, 3, and 4 doses, respectively.Conclusions SOTRs are at significantly higher risk for severe COVID-19 compared to non-SOTRs. Vaccination is effective in preventing the progression to severe COVID-19. Efforts should be made to improve vaccine uptake among SOTRs, while additional protective measures should be developed. In this nationwide claims-based study in Korea, the risk of severe COVID-19 was significantly higher in solid organ transplant recipients (SOTRs) compared to non-SOTRs. Vaccination showed significant effectiveness in reducing the risk of severe COVID-19 among SOTRs. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | OXFORD UNIV PRESS INC | - |
dc.title | Risk of Severe COVID-19 and Protective Effectiveness of Vaccination Among Solid Organ Transplant Recipients | - |
dc.type | Article | - |
dc.identifier.wosid | 001126492200001 | - |
dc.identifier.doi | 10.1093/infdis/jiad501 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INFECTIOUS DISEASES, v.229, no.4, pp 1026 - 1034 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85190479712 | - |
dc.citation.endPage | 1034 | - |
dc.citation.startPage | 1026 | - |
dc.citation.title | JOURNAL OF INFECTIOUS DISEASES | - |
dc.citation.volume | 229 | - |
dc.citation.number | 4 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | COVID-19 | - |
dc.subject.keywordAuthor | organ transplantation | - |
dc.subject.keywordAuthor | vaccines | - |
dc.subject.keywordAuthor | big data | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | EPIDEMIOLOGY | - |
dc.subject.keywordPlus | VACCINES | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.