Role of Inhibitory Transforming Growth Factor-β Signal Smad7 in Helicobacter pylori-associated Gastric Damage
DC Field | Value | Language |
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dc.contributor.author | 이호재 | - |
dc.contributor.author | 박종민 | - |
dc.contributor.author | 함기백 | - |
dc.date.available | 2020-02-28T04:43:13Z | - |
dc.date.created | 2020-02-12 | - |
dc.date.issued | 2016-10 | - |
dc.identifier.issn | 1598-9992 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/9116 | - |
dc.description.abstract | Background/Aims: Transforming growth factor-beta (TGF-) is a cytokine implicated in the susceptibility, development, and progression of gastrointestinal cancer and certain other neoplasms. In the later stages of cancer, TGF- not only acts as a bystander of host-immune response, but also contributes to cell growth, invasion, and metastasis. In the current study, we generated gastric mucosal cells that stably express Smad7, and explored the Helicobacter pylori-associated biological changes between mock-transfected and Smad7-transfected RGM1 cells. Methods: RGM1 cells stably transfected with Smad7 were infected with H. pylori, and molecular changes in apoptotic markers and inflammatory mediators were examined. Several candidate genes were explored in Smad7-overexpressing cells after H. pylori infection. Results: Overexpression of Smad7 in RGM1 cells significantly increased the H. pylori-induced cytotoxicity compared to mock-transfected cells. Exaggerated increases in inflammatory mediators, cyclooxygenase 2, inducible NO synthase, and augmented apoptosis were noted in Smad7-overexpressing cells, whereas mitigated heme oxygenase 1 was noted in Smad7- overexpressing cells. These phenomena were reversed in cells transfected with Smad7 siRNA. Conclusions: These data suggest that inhibition of Smad7 is a possible target for mitigating H. pylori-associated inflammation. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | 대한소화기학회 | - |
dc.relation.isPartOf | 대한소화기학회지 | - |
dc.title | Role of Inhibitory Transforming Growth Factor-β Signal Smad7 in Helicobacter pylori-associated Gastric Damage | - |
dc.title.alternative | 헬리코박터 파일로리 감염 연관 위질환 발생시 형질전환인자-베타 저해신호로서 Smad7의 역할 | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.doi | 10.4166/kjg.2016.68.4.186 | - |
dc.identifier.bibliographicCitation | 대한소화기학회지, v.68, no.4, pp.186 - 194 | - |
dc.identifier.kciid | ART002158979 | - |
dc.identifier.scopusid | 2-s2.0-85018597985 | - |
dc.citation.endPage | 194 | - |
dc.citation.startPage | 186 | - |
dc.citation.title | 대한소화기학회지 | - |
dc.citation.volume | 68 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | 이호재 | - |
dc.subject.keywordAuthor | Helicobacter pylori | - |
dc.subject.keywordAuthor | Transforming growth factor beta | - |
dc.subject.keywordAuthor | Smad7 | - |
dc.subject.keywordAuthor | Gastritis | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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