Scallop-derived plasmalogen attenuates amyloid beta-induced inflammation and apoptosis in SH-SY5Y cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Han, Jin-Young | - |
dc.contributor.author | Park, Miey | - |
dc.contributor.author | Lee, Hae-Jeung | - |
dc.date.accessioned | 2024-05-20T12:00:18Z | - |
dc.date.available | 2024-05-20T12:00:18Z | - |
dc.date.issued | 2024-04 | - |
dc.identifier.issn | 1738-642X | - |
dc.identifier.issn | 2092-8467 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/91232 | - |
dc.description.abstract | BackgroundsWith an increase in the world's aging population, candidate substances for the management of neurodegenerative diseases, including Alzheimer's disease (AD), have received considerable attention. Amyloid beta (A beta) peptide, the leading cause of AD, induces synaptic deficits, eventually leading to cognitive impairment. Plasmalogen is a subclass of glycerophospholipids containing a vinyl ether group in the glycerol backbone which has various efficacies.ObjectivesIn this study, we investigated the mechanisms of scallop-derived plasmalogen (SPL) in neurotoxicity in human neurons, which remain incompletely understood. SH-SY5Y human neuroblastaoma cells were treated with A beta 1-42, a major component of amyloid deposits in AD brains.ResultsSPL inhibited the phosphorylation of glycogen synthase kinase 3 beta and tau induced by A beta. In addition, SPL decreased A beta generation by downregulating the expression of amyloid precursor protein (APP) and beta-site APP cleaving enzyme 1. Furthermore, SPL suppressed the release of pro-inflammatory cytokines and expression of apoptotic proteins induced by A beta.ConclusionOur study indicates that SPL would reduce A beta-induced neurotoxicity associated with inflammation and apoptosis in human neuroblastoma cells. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN SOCIETY TOXICOGENOMICS & TOXICOPROTEOMICS-KSTT | - |
dc.title | Scallop-derived plasmalogen attenuates amyloid beta-induced inflammation and apoptosis in SH-SY5Y cells | - |
dc.type | Article | - |
dc.identifier.wosid | 001082588000001 | - |
dc.identifier.doi | 10.1007/s13273-023-00399-2 | - |
dc.identifier.bibliographicCitation | MOLECULAR & CELLULAR TOXICOLOGY, v.20, no.2, pp 421 - 430 | - |
dc.identifier.kciid | ART003069317 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85174158627 | - |
dc.citation.endPage | 430 | - |
dc.citation.startPage | 421 | - |
dc.citation.title | MOLECULAR & CELLULAR TOXICOLOGY | - |
dc.citation.volume | 20 | - |
dc.citation.number | 2 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Scallop-derived plasmalogen | - |
dc.subject.keywordAuthor | Amyloid beta | - |
dc.subject.keywordAuthor | SH-SY5Y cells | - |
dc.subject.keywordAuthor | Neurotoxicity | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.