A Two-Year Observational Study to Evaluate Conversion Rates from High- and Low-Risk Patients with Amnestic Mild Cognitive Impairment to Probable Alzheimer's Disease in a Real-World Setting
DC Field | Value | Language |
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dc.contributor.author | Jang, H. | - |
dc.contributor.author | Na, D.L. | - |
dc.contributor.author | Kwon, J.C. | - |
dc.contributor.author | Jung, N.-Y. | - |
dc.contributor.author | Moon, Y. | - |
dc.contributor.author | Lee, J.S. | - |
dc.contributor.author | Park, K.-W. | - |
dc.contributor.author | Lee, A.Y. | - |
dc.contributor.author | Cho, H. | - |
dc.contributor.author | Lee, J.-H. | - |
dc.contributor.author | Kim, B.C. | - |
dc.contributor.author | Park, K.H. | - |
dc.contributor.author | Lee, B.-C. | - |
dc.contributor.author | Choi, H. | - |
dc.contributor.author | Kim, J. | - |
dc.contributor.author | Park, M.Y. | - |
dc.date.accessioned | 2024-05-28T12:30:34Z | - |
dc.date.available | 2024-05-28T12:30:34Z | - |
dc.date.issued | 2024-05 | - |
dc.identifier.issn | 2542-4823 | - |
dc.identifier.issn | 2542-4823 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/91370 | - |
dc.description.abstract | Background: Predicting conversion to probable Alzheimers disease (AD) from amnestic mild cognitive impairment (aMCI) is difficult but important. A nomogram was developed previously for determining the risk of 3-year probable AD conversion in aMCI. Objective: To compare the probable AD conversion rates with cognitive and neurodegenerative changes for 2 years from high- and low risk aMCI groups classified using the nomogram. Methods: This prospective, multicenter, observational study was conducted in Korea. A total of patients were classified as high- or low-risk aMCI according to the nomogram and followed-up for 2 years to compare the annual conversion rate to probable AD and brain structure changes between the two groups. Results: In total, 176 (high-risk, 85; low-risk, 91) and 160 (high-risk, 77; low-risk, 83) patients completed the 1-year and 2-year follow-up, respectively. The probable AD conversion rate was significantly higher in the high-risk (Year 1, 28.9%; Year 2, 46.1%) versus low-risk group (Year 1, 0.0%; Year 2, 4.9%, both p < 0.0001). Mean changes from baseline in Seoul Neuropsychological Screening Battery-Dementia Version, Clinical Dementia Rating-Sum of Box, and Korean version of the Instrumental Activities of Daily Living scores and cortical atrophy index at Years 1 and 2 were significantly greater in the high-risk group (p < 0.0001). Conclusions: The high-risk aMCI group, as determined by the nomogram, had a higher conversion rate to probable AD and faster cognitive decline and neurodegeneration change than the low-risk group. These real-world results have clinical implications that help clinicians in accurately predicting patient outcomes and facilitating early decision-making. Trial Registration: ClinicalTrials.gov (NCT03448445) © 2024 - The authors. Published by IOS Press. | - |
dc.format.extent | 12 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | IOS Press BV | - |
dc.title | A Two-Year Observational Study to Evaluate Conversion Rates from High- and Low-Risk Patients with Amnestic Mild Cognitive Impairment to Probable Alzheimer's Disease in a Real-World Setting | - |
dc.type | Article | - |
dc.identifier.wosid | 001234523100006 | - |
dc.identifier.doi | 10.3233/ADR-230189 | - |
dc.identifier.bibliographicCitation | Journal of Alzheimer's Disease Reports, v.8, no.1, pp 851 - 862 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85193747302 | - |
dc.citation.endPage | 862 | - |
dc.citation.startPage | 851 | - |
dc.citation.title | Journal of Alzheimer's Disease Reports | - |
dc.citation.volume | 8 | - |
dc.citation.number | 1 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | Alzheimer's disease | - |
dc.subject.keywordAuthor | amnestic mild cognitive impairment | - |
dc.subject.keywordAuthor | conversion rate | - |
dc.subject.keywordAuthor | neurodegeneration | - |
dc.subject.keywordAuthor | neuropsychometry | - |
dc.subject.keywordAuthor | nomogram | - |
dc.subject.keywordPlus | DEMENTIA | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | THICKNESS | - |
dc.subject.keywordPlus | MRI | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | esci | - |
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