Glycated albumin as a surrogate marker for prediabetes: a cross-sectional study
DC Field | Value | Language |
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dc.contributor.author | Alam, Sana | - |
dc.contributor.author | Ahmad, Fahad | - |
dc.contributor.author | Tripathi, Prashant | - |
dc.contributor.author | Raghav, Alok | - |
dc.date.accessioned | 2024-06-05T01:01:04Z | - |
dc.date.available | 2024-06-05T01:01:04Z | - |
dc.date.issued | 2024-06 | - |
dc.identifier.issn | 0973-3930 | - |
dc.identifier.issn | 1998-3832 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/91442 | - |
dc.description.abstract | Objective Oral glucose tolerance test (OGTT) and glycated haemoglobin (HbA1c) have many limitations in diagnosing prediabetes. Glycated albumin (GA) estimation can be a potential tool for its early diagnosis. The present study aims to analyze the diagnostic efficacy of GA to identify prediabetes. Methods Prediabetics (n = 406) and healthy (n = 406) subjects were included. OGTT was used as the diagnostic standard for identifying prediabetes. HbA1c was estimated in a Bio-Rad D-10 analyzer based on the High-Performance Liquid Chromatography (HPLC) method. GA was measured using the enzyme-linked immunosorbent assay (ELISA) technique and was expressed as a percent of total albumin. Total albumin was measured by the modified bromocresol Purple (BCP) dye-binding method in Siemen's autoanalyzer. Results HbA1c (5.83 +/- 0.57%) and GA (14.43 +/- 1.92%) were significantly higher (p < 0.05) in the prediabetics as compared to healthy individuals. Both HbA1c and GA showed a significantly positive correlation with fasting plasma glucose (FPG) and 2-h plasma glucose. However, the correlation was stronger with 2-h plasma glucose for both parameters. GA and HbA1c also showed a significant positive correlation with each other. HbA1c, at 5.7% cut-off, predicted prediabetes with 74% sensitivity and 90% specificity. At the cut-off of 13.5%, GA showed 66% sensitivity and 85% specificity to identify pre-diabetes. The sensitivity of the combined tests was significantly greater than that for HbA1c alone (84% combined versus 74% HbA1c). Conclusion GA, combined with HbA1c, can be used as a screening test for identifying pre-diabetes. Early diagnosis and interventions could prevent disease progression and limit dreadful complications. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SPRINGER INDIA | - |
dc.title | Glycated albumin as a surrogate marker for prediabetes: a cross-sectional study | - |
dc.type | Article | - |
dc.identifier.wosid | 001070897400001 | - |
dc.identifier.doi | 10.1007/s13410-023-01250-z | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES, v.44, no.2, pp 379 - 386 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85171475211 | - |
dc.citation.endPage | 386 | - |
dc.citation.startPage | 379 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES | - |
dc.citation.volume | 44 | - |
dc.citation.number | 2 | - |
dc.type.docType | Article | - |
dc.publisher.location | 인도 | - |
dc.subject.keywordAuthor | Prediabetes | - |
dc.subject.keywordAuthor | Glycated albumin | - |
dc.subject.keywordAuthor | Diabetes mellitus | - |
dc.subject.keywordAuthor | Marker | - |
dc.subject.keywordAuthor | HbA1c | - |
dc.subject.keywordPlus | CHRONIC KIDNEY-DISEASE | - |
dc.subject.keywordPlus | DIABETES-MELLITUS | - |
dc.subject.keywordPlus | HEMOGLOBIN A(1C) | - |
dc.subject.keywordPlus | GLYCEMIC CONTROL | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | UTILITY | - |
dc.subject.keywordPlus | ADULTS | - |
dc.subject.keywordPlus | INDEX | - |
dc.subject.keywordPlus | RISK | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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