Non-papillary thyroid carcinoma diagnoses in The Bethesda System for Reporting Thyroid Cytopathology categories V and VI: An institutional experience
DC Field | Value | Language |
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dc.contributor.author | Kang, Myunghee | - |
dc.contributor.author | Kim, Na Rae | - |
dc.contributor.author | Seok, Jae Yeon | - |
dc.date.accessioned | 2024-06-14T11:30:25Z | - |
dc.date.available | 2024-06-14T11:30:25Z | - |
dc.date.issued | 2024-08 | - |
dc.identifier.issn | 1092-9134 | - |
dc.identifier.issn | 1532-8198 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/91503 | - |
dc.description.abstract | Background: The non-papillary thyroid carcinoma (PTC) subgroups of The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) categories V (Suspicious for malignancy) and VI (Malignant) are rare, and specific tumor typing is difficult. We aimed to analyze histologic outcomes and to investigate the points of caution. Methods: We reviewed the electronic database and identified 12,215 cases of thyroid fine-needle aspiration cytology between 2013 and 2022. In total, 2783 patients were diagnosed with TBSRTC V or VI. Of these, 51 patients with non-PTC diagnosis were identified. Histological outcomes were analyzed with the cytologic findings. Results: The subgroups of non-PTC diagnoses in TBSRTC category V or VI consisted of medullary thyroid carcinoma (MTC) (13/51, 25.5 %), anaplastic thyroid carcinoma (3/51, 5.9 %), lymphoma (2/51, 3.9 %), metastatic tumor (4/51, 7.8 %), and malignant, not otherwise specified (NOS) (29/51, 56.9 %). The concordance rate of the histological outcomes was 30 % (12/40), predominantly comprising MTC cases. The obscuring factors for specific tumor typing in the suspicious for malignancy/malignant NOS cytology diagnosis group was mixed pattern of well differentiated thyroid carcinoma and less differentiated carcinoma cells (9/24, 37.5 %), low cellularity (7/24, 29.2 %) and a history of non-thyroid organ malignancy (6/24, 25 %). The less differentiated carcinoma component in mixed pattern consisted of 2 poorly differentiated thyroid carcinomas, 2 anaplastic thyroid carcinomas, 4 high-grade PTCs and 1 high-grade MTC. Conclusion: The high-grade feature of PTC or MTC cytology is a noteworthy obscuring factor in specific tumor typing of non-PTC cytology diagnosis. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Non-papillary thyroid carcinoma diagnoses in The Bethesda System for Reporting Thyroid Cytopathology categories V and VI: An institutional experience | - |
dc.type | Article | - |
dc.identifier.wosid | 001216664600001 | - |
dc.identifier.doi | 10.1016/j.anndiagpath.2023.152263 | - |
dc.identifier.bibliographicCitation | ANNALS OF DIAGNOSTIC PATHOLOGY, v.71 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85181955030 | - |
dc.citation.title | ANNALS OF DIAGNOSTIC PATHOLOGY | - |
dc.citation.volume | 71 | - |
dc.type.docType | Article | - |
dc.publisher.location | United States | - |
dc.subject.keywordAuthor | Thyroid | - |
dc.subject.keywordAuthor | Cytology | - |
dc.subject.keywordAuthor | Medullary Thyroid Carcinoma | - |
dc.subject.keywordAuthor | Anaplastic Thyroid Carcinoma | - |
dc.subject.keywordAuthor | Metastasis | - |
dc.subject.keywordAuthor | Differential Diagnosis | - |
dc.subject.keywordAuthor | High -Grade | - |
dc.subject.keywordPlus | TO-TUMOR METASTASIS | - |
dc.subject.keywordPlus | CRIBRIFORM-MORULAR VARIANT | - |
dc.subject.keywordPlus | FINE-NEEDLE-ASPIRATION | - |
dc.subject.keywordPlus | HURTHLE CELL ADENOMA | - |
dc.subject.keywordPlus | FOLLICULAR ADENOMA | - |
dc.subject.keywordPlus | FEATURES | - |
dc.relation.journalResearchArea | Pathology | - |
dc.relation.journalWebOfScienceCategory | Pathology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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