Rosarugosides A and D from Rosa rugosa Flower Buds: Their Potential Anti-Skin-Aging Effects in TNF-α-Induced Human Dermal Fibroblasts
DC Field | Value | Language |
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dc.contributor.author | Kim, Kang Sub | - |
dc.contributor.author | Son, So-Ri | - |
dc.contributor.author | Choi, Yea Jung | - |
dc.contributor.author | Kim, Yejin | - |
dc.contributor.author | Ahn, Si-Young | - |
dc.contributor.author | Jang, Dae Sik | - |
dc.contributor.author | Lee, Sullim | - |
dc.date.accessioned | 2024-06-15T16:00:31Z | - |
dc.date.available | 2024-06-15T16:00:31Z | - |
dc.date.issued | 2024-05 | - |
dc.identifier.issn | 2223-7747 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/91528 | - |
dc.description.abstract | This present study investigated the anti-skin-aging properties of Rosa rugosa. Initially, phenolic compounds were isolated from a hot water extract of Rosa rugosa's flower buds. Through repeated chromatography (column chromatography, MPLC, and prep HPLC), we identified nine phenolic compounds (1-9), including a previously undescribed depside, rosarugoside D (1). The chemical structure of 1 was elucidated via NMR, HR-MS, UV, and hydrolysis. Next, in order to identify bioactive compounds that are effective against TNF-alpha-induced NHDF cells, we measured intracellular ROS production in samples treated with each of the isolated compounds (1-9). All isolates reduced the level of ROS at a concentration of 10 mu M. Particularly, two depsides-rosarugosides A and D (2 and 1)-significantly inhibited ROS expression in TNF-alpha-induced NHDFs compared to the other phenolic compounds. Subsequently, the production of MMP-1 and procollagen type Iota alpha 1 by these two depsides was examined. Remarkably, rosarugoside A (2) significantly decreased MMP-1 secretion at all concentrations. In contrast, rosarugoside D (1) regulated the expression of procollagen type Iota alpha 1. These findings collectively suggest that Rosa rugosa extracts and their isolated compounds, rosarugosides A (2) and D (1), hold significant potential for protecting against aging and skin damage. Overall, these findings suggest that Rosa rugosa extracts and their isolated compounds, rosarugosides A (2) and D (1), have the potential to prevent and protect against aging and skin damage, although more specific quantitative analysis is needed. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI | - |
dc.title | Rosarugosides A and D from Rosa rugosa Flower Buds: Their Potential Anti-Skin-Aging Effects in TNF-α-Induced Human Dermal Fibroblasts | - |
dc.type | Article | - |
dc.identifier.wosid | 001220525200001 | - |
dc.identifier.doi | 10.3390/plants13091266 | - |
dc.identifier.bibliographicCitation | PLANTS-BASEL, v.13, no.9 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85192710325 | - |
dc.citation.title | PLANTS-BASEL | - |
dc.citation.volume | 13 | - |
dc.citation.number | 9 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | Rosa rugosa | - |
dc.subject.keywordAuthor | depsides | - |
dc.subject.keywordAuthor | TNF-alpha | - |
dc.subject.keywordAuthor | ROS | - |
dc.subject.keywordAuthor | MMP-1 | - |
dc.subject.keywordAuthor | procollagen type Iota alpha 1 | - |
dc.subject.keywordPlus | MATRIX METALLOPROTEINASES | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | CONSTITUENTS | - |
dc.subject.keywordPlus | PROTECTION | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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