Body mass index and meniscal tears: Evidence from meta-analysis of observational studies and Mendelian randomization
DC Field | Value | Language |
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dc.contributor.author | Lee, Jung Hoon | - |
dc.contributor.author | Oh, Seungyeop | - |
dc.contributor.author | Kim, Kihun | - |
dc.contributor.author | Lee, Dongjun | - |
dc.contributor.author | Son, Eunjeong | - |
dc.contributor.author | Kim, Tae Woo | - |
dc.contributor.author | Goh, Tae Sik | - |
dc.contributor.author | Cho, Noo Ree | - |
dc.contributor.author | Kim, Yun Hak | - |
dc.date.accessioned | 2024-06-18T13:30:19Z | - |
dc.date.available | 2024-06-18T13:30:19Z | - |
dc.date.issued | 2024-07 | - |
dc.identifier.issn | 1467-7881 | - |
dc.identifier.issn | 1467-789X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/91544 | - |
dc.description.abstract | Obesity is a potential risk factor for meniscal tear (MT). We utilized meta-analysis of observational studies and Mendelian randomization (MR) analyses to elucidate the association between body mass index (BMI) and MT. In meta-analysis, a search was performed on June 27, 2022, using PubMed and Embase databases. Odds ratios and 95% confidence intervals were extracted from included studies. In MR analyses, the research utilized summary-level data on BMI and MT obtained from Genetic Investigation of Anthropometric Traits and the FinnGen Consortium, respectively. In meta-analysis, four studies comprising 826,383 participants were included. The pooled odds ratio of MT in the high BMI group was 1.32 (95% confidence interval, 0.83-2.09), compared with the nonhigh BMI group. The pooled odds ratio in the under 30 group was 1.76 (95% confidence interval, 0.61-5.03). In MR analyses, one standard deviation increase in genetically predicted BMI was associated with meniscus derangement as a chronic subtype of MT (odds ratio, 1.36; 95% confidential interval, 1.17-1.59). We found that a high BMI was not associated with an increased likelihood of MT based on meta-analysis of observational studies; however, by complementing MR analyses, we elucidated the causality of BMI increase on meniscus derangement as a chronic subtype of MT. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY | - |
dc.title | Body mass index and meniscal tears: Evidence from meta-analysis of observational studies and Mendelian randomization | - |
dc.type | Article | - |
dc.identifier.wosid | 001201943800001 | - |
dc.identifier.doi | 10.1111/obr.13749 | - |
dc.identifier.bibliographicCitation | OBESITY REVIEWS, v.25, no.7 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85190939871 | - |
dc.citation.title | OBESITY REVIEWS | - |
dc.citation.volume | 25 | - |
dc.citation.number | 7 | - |
dc.type.docType | Review | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | body mass index | - |
dc.subject.keywordAuthor | Mendelian randomization | - |
dc.subject.keywordAuthor | meniscal tear | - |
dc.subject.keywordAuthor | meta-analysis | - |
dc.subject.keywordAuthor | systematic review | - |
dc.subject.keywordPlus | RISK-FACTORS | - |
dc.subject.keywordPlus | MICROVASCULATURE | - |
dc.subject.keywordPlus | OSTEOARTHRITIS | - |
dc.subject.keywordPlus | INJURIES | - |
dc.subject.keywordPlus | INSIGHTS | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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