Potential Role of Dietary Salmon Nasal Cartilage Proteoglycan on UVB-Induced Photoaged Skin
DC Field | Value | Language |
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dc.contributor.author | Lee, Hae Ran | - |
dc.contributor.author | Hong, Seong-Min | - |
dc.contributor.author | Cho, Kyohee | - |
dc.contributor.author | Kim, Seon Hyeok | - |
dc.contributor.author | Ko, Eunji | - |
dc.contributor.author | Lee, Eunyoo | - |
dc.contributor.author | Kim, Hyun Jin | - |
dc.contributor.author | Jeon, Se Yeong | - |
dc.contributor.author | Do, Seon Gil | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.date.accessioned | 2024-06-20T12:00:38Z | - |
dc.date.available | 2024-06-20T12:00:38Z | - |
dc.date.issued | 2024-03 | - |
dc.identifier.issn | 1976-9148 | - |
dc.identifier.issn | 2005-4483 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/91595 | - |
dc.description.abstract | New supplements with preventive effects against skin photodamage are receiving increasing attention. This study evaluated the anti-photoaging effects of salmon nasal cartilage proteoglycan (SPG), acting as a functional material for skin health. We administered SPG to in vitro and in vivo models exposed to ultraviolet B (UVB) radiation and assessed its moisturizing and anti -wrinkle effects on dorsal mouse skin and keratinocytes and dermal fibroblasts cell lines. These results showed that SPG restored the levels of filaggrin, involucrin, and AQP3 in the epidermis of UVB-irradiated dorsal skin and keratinocytes, thereby enhancing the keratinization process and water flow. Additionally, SPG treatment increased the levels of hyaluronan and skin ceramide, the major components of intercellular lipids in the epidermis. Furthermore, SPG treatment significantly increased the levels of collagen and procollagen type 1 by down -regulating matrix metalloproteinase 1, which play a crucial role in skin fibroblasts, in both in vitro and in vivo models. In addition, SPG strongly inhibited mitogen-activated protein kinase (MAPKs) signaling, the including extracellular signal -regulated kinase, c -Jun N -terminal kinase (JNK), and p38. These findings suggest that dietary SPG may be an attractive functional food for preventing UVB-induced photoaging. And this SPG product may provide its best benefit when treating several signs of skin photoaging. | - |
dc.format.extent | 12 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN SOC APPLIED PHARMACOLOGY | - |
dc.title | Potential Role of Dietary Salmon Nasal Cartilage Proteoglycan on UVB-Induced Photoaged Skin | - |
dc.type | Article | - |
dc.identifier.wosid | 001206880500003 | - |
dc.identifier.doi | 10.4062/biomolther.2024.010 | - |
dc.identifier.bibliographicCitation | BIOMOLECULES & THERAPEUTICS, v.32, no.2, pp 249 - 260 | - |
dc.identifier.kciid | ART003055095 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85186459572 | - |
dc.citation.endPage | 260 | - |
dc.citation.startPage | 249 | - |
dc.citation.title | BIOMOLECULES & THERAPEUTICS | - |
dc.citation.volume | 32 | - |
dc.citation.number | 2 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Salmon nasal cartilage proteoglycan | - |
dc.subject.keywordAuthor | UVB-irradiated photoaging | - |
dc.subject.keywordAuthor | Skin barrier function | - |
dc.subject.keywordAuthor | Skin hydration | - |
dc.subject.keywordAuthor | Wrinkles | - |
dc.subject.keywordAuthor | MAPKs | - |
dc.subject.keywordPlus | CERAMIDE | - |
dc.subject.keywordPlus | FIBROBLAST | - |
dc.subject.keywordPlus | COLLAGEN | - |
dc.subject.keywordPlus | SERUM | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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