Functionalized Carbon Quantum Dots Derived from Zelkova serrata Plant Leaves for the Detection of Normetanephrine in Geriatric Plasma Samples and ROS-Induced Antibacterial Applications Using a Plausible Mechanistic Approach
DC Field | Value | Language |
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dc.contributor.author | Poojitha, Yanamala | - |
dc.contributor.author | Chellasamy, Gayathri | - |
dc.contributor.author | Govindaraju, Saravanan | - |
dc.contributor.author | Yun, Kyusik | - |
dc.date.accessioned | 2024-07-06T11:00:26Z | - |
dc.date.available | 2024-07-06T11:00:26Z | - |
dc.date.issued | 2024-06 | - |
dc.identifier.issn | 1976-0280 | - |
dc.identifier.issn | 2092-7843 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/91719 | - |
dc.description.abstract | Functionalized carbon quantum dots with tunable optical properties widely used in sensor applications. In this study, carbon quantum dots were synthesized from Zelkova serrata leaves (ZCQDs) in an aqueous medium via a single-step hydrothermal reaction with essential reactive functional groups. As-synthesized ZCQDs (average size, 3-7 nm) were characterized and confirmed to contain hydroxyl/amine and carboxylic acid functional groups. Photoluminescence spectral analysis revealed that the fluorescence intensity of ZCQDs drastically decreased after the addition of different concentrations of normetanephrine (NM) in deionized water and geriatric plasma samples. Our developed strategy could detect NM with a limit of detection of 7.96 and 86.2 nM in deionized water and geriatric plasma samples, respectively. Interestingly, Fourier transform infrared spectroscopy revealed a new peak at 1660 cm(-1), confirming the formation of the keto (C=O) group in NM. In addition, significant peak shifts were observed in the C 1s, and O 1s deconvoluted X-ray photoelectron spectra. Bandgap calculations also revealed significant interactions between NM and ZCQDs. Antibacterial activities of ZCQDs were investigated in Escherichia coli and Staphylococcus aureus, and potent activities were observed in Staphylococcus aureus at a half-maximal inhibitory concentration of 32 mu g/mL via the generation of intracellular reactive oxygen species. By enabling specific therapies and improving our understanding of intricate biological processes at the nanoscale, these materials have the potential to completely transform the biomedical field. Our findings suggest the involvement of a working mechanism in transferring electrons between the conductance band of ZCQDs and the acidic protons of N, to produce the oxidized form NM for photoluminescence quenching of ZCQDs. | - |
dc.format.extent | 14 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN BIOCHIP SOCIETY-KBCS | - |
dc.title | Functionalized Carbon Quantum Dots Derived from Zelkova serrata Plant Leaves for the Detection of Normetanephrine in Geriatric Plasma Samples and ROS-Induced Antibacterial Applications Using a Plausible Mechanistic Approach | - |
dc.type | Article | - |
dc.identifier.wosid | 001161044400001 | - |
dc.identifier.doi | 10.1007/s13206-023-00136-w | - |
dc.identifier.bibliographicCitation | BIOCHIP JOURNAL, v.18, no.2, pp 233 - 246 | - |
dc.identifier.kciid | ART003088904 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85184911440 | - |
dc.citation.endPage | 246 | - |
dc.citation.startPage | 233 | - |
dc.citation.title | BIOCHIP JOURNAL | - |
dc.citation.volume | 18 | - |
dc.citation.number | 2 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Zelkova serrata leaves | - |
dc.subject.keywordAuthor | Carbon quantum dots | - |
dc.subject.keywordAuthor | Normetanephrine | - |
dc.subject.keywordAuthor | Photoluminescence quenching | - |
dc.subject.keywordAuthor | Geriatric plasma | - |
dc.subject.keywordAuthor | Antibacterial activity | - |
dc.subject.keywordPlus | PROBES | - |
dc.subject.keywordPlus | IONS | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Biochemical Research Methods | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Analytical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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