Recent Advances in IRAK1: Pharmacological and Therapeutic Aspects
DC Field | Value | Language |
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dc.contributor.author | Kim, Kyeong Min | - |
dc.contributor.author | Hwang, Na-Hee | - |
dc.contributor.author | Hyun, Ja-Shil | - |
dc.contributor.author | Shin, Dongyun | - |
dc.date.accessioned | 2024-07-06T11:00:32Z | - |
dc.date.available | 2024-07-06T11:00:32Z | - |
dc.date.issued | 2024-05 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/91732 | - |
dc.description.abstract | Interleukin receptor-associated kinase (IRAK) proteins are pivotal in interleukin-1 and Toll-like receptor-mediated signaling pathways. They play essential roles in innate immunity and inflammation. This review analyzes and discusses the physiological functions of IRAK1 and its associated diseases. IRAK1 is involved in a wide range of diseases such as dry eye, which highlights its potential as a therapeutic target under various conditions. Various IRAK1 inhibitors, including Pacritinib and Rosoxacin, show therapeutic potential against malignancies and inflammatory diseases. The covalent IRAK1 inhibitor JH-X-119-01 shows promise in B-cell lymphomas, emphasizing the significance of covalent bonds in its activity. Additionally, the emergence of selective IRAK1 degraders, such as JNJ-101, provides a novel strategy by targeting the scaffolding function of IRAK1. Thus, the evolving landscape of IRAK1-targeted approaches provides promising avenues for increasingly safe and effective therapeutic interventions for various diseases. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI | - |
dc.title | Recent Advances in IRAK1: Pharmacological and Therapeutic Aspects | - |
dc.type | Article | - |
dc.identifier.wosid | 001231490000001 | - |
dc.identifier.doi | 10.3390/molecules29102226 | - |
dc.identifier.bibliographicCitation | MOLECULES, v.29, no.10 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85194219494 | - |
dc.citation.title | MOLECULES | - |
dc.citation.volume | 29 | - |
dc.citation.number | 10 | - |
dc.type.docType | Review | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | interleukin receptor-associated kinase (IRAK) proteins | - |
dc.subject.keywordAuthor | inhibitor | - |
dc.subject.keywordAuthor | degrader | - |
dc.subject.keywordAuthor | immunity | - |
dc.subject.keywordPlus | SIGNALING MEDIATOR | - |
dc.subject.keywordPlus | KINASE IRAK | - |
dc.subject.keywordPlus | INNATE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | INHIBITORS | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordPlus | NEUROINFLAMMATION | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | MICRORNA-146A | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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