Activated carbon nanofiber nanoparticles incorporated electrospun polycaprolactone scaffolds to promote fibroblast behaviors for application to skin tissue engineering
DC Field | Value | Language |
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dc.contributor.author | Choi, Sangmun | - |
dc.contributor.author | Raja, Iruthayapandi Selestin | - |
dc.contributor.author | Selvaraj, Aravindha Raja | - |
dc.contributor.author | Kang, Moon Sung | - |
dc.contributor.author | Park, Tae-Eon | - |
dc.contributor.author | Kim, Ki Su | - |
dc.contributor.author | Hyon, Suong-Hyu | - |
dc.contributor.author | Han, Dong-Wook | - |
dc.contributor.author | Park, Jong-Chul | - |
dc.date.accessioned | 2024-07-08T05:00:30Z | - |
dc.date.available | 2024-07-08T05:00:30Z | - |
dc.date.issued | 2023-02 | - |
dc.identifier.issn | 2522-0128 | - |
dc.identifier.issn | 2522-0136 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/91797 | - |
dc.description.abstract | The most widely used one-dimensional (1D) carbonaceous nanomaterials in tissue engineering are carbon nanotubes, either single or multiwalled. Other forms of 1D nanomaterials, such as carbon nanowires and carbon nanofibers, have been less explored for biomedical applications. Herein, we synthesized 1D-activated carbon nanofiber nanoparticles (ACNF NPs) from the polyacrylonitrile electrospun nanofibers by continuous processes like stabilization, alkali treatment, calcination, and grinding. Two different sets of ACNF NPs-containing electrospun polycaprolactone (PCL) nanofiber mats, viz. surface-modified NP-deposited mats (ACNF@PCL) and NP-incorporated mats (ACNF-PCL), were prepared to examine their potential as skin tissue engineering scaffolds. Raman spectra demonstrated that ACNF NPs exhibited graphitization degree with an I-D/I-G ratio of 1.05. Scanning electron microscopy (SEM) observations showed that ACNF NPs are sized 280 +/- 100 nm by diameter and 565-3322 nm by length. The NPs concentrated above 30 mu g/mL were found to exhibit toxicity with < 70% viability of NIH3T3 fibroblasts on 48 h. The ACNF-PCL nanofiber mats displayed better cell proliferation profile showing significant changes compared to PCL and ACNF@PCL mats on days 1, 3, and 5. Hence, we concluded that ACNF-PCL mats with less concentration of ACNF NPs have more potential to support cellular growth, ensuring its possible impact on skin tissue regeneration. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SPRINGERNATURE | - |
dc.title | Activated carbon nanofiber nanoparticles incorporated electrospun polycaprolactone scaffolds to promote fibroblast behaviors for application to skin tissue engineering | - |
dc.type | Article | - |
dc.identifier.wosid | 000904138200002 | - |
dc.identifier.doi | 10.1007/s42114-022-00608-x | - |
dc.identifier.bibliographicCitation | ADVANCED COMPOSITES AND HYBRID MATERIALS, v.6, no.1 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85144609020 | - |
dc.citation.title | ADVANCED COMPOSITES AND HYBRID MATERIALS | - |
dc.citation.volume | 6 | - |
dc.citation.number | 1 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Electrospun nanofiber | - |
dc.subject.keywordAuthor | Activated carbon nanofiber nanoparticles | - |
dc.subject.keywordAuthor | Polycaprolactone | - |
dc.subject.keywordAuthor | Skin tissue engineering | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Composites | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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