Risk of on-treatment lymphopenia is associated with treatment outcome and efficacy of consolidation immunotherapy in patients with non-small cell lung cancer treated with concurrent chemoradiotherapy
DC Field | Value | Language |
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dc.contributor.author | Yang, Gowoon | - |
dc.contributor.author | Yoon, Hong In | - |
dc.contributor.author | Lee, Joongyo | - |
dc.contributor.author | Kim, Jihun | - |
dc.contributor.author | Kim, Hojin | - |
dc.contributor.author | Cho, Jaeho | - |
dc.contributor.author | Lee, Chang Geol | - |
dc.contributor.author | Chang, Jee Suk | - |
dc.contributor.author | Cho, Yeona | - |
dc.contributor.author | Kim, Jin Sung | - |
dc.contributor.author | Kim, Kyung Hwan | - |
dc.date.accessioned | 2024-07-08T05:00:38Z | - |
dc.date.available | 2024-07-08T05:00:38Z | - |
dc.date.issued | 2023-12 | - |
dc.identifier.issn | 0167-8140 | - |
dc.identifier.issn | 1879-0887 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/91853 | - |
dc.description.abstract | Background and purpose: The ability of the effective dose to immune cells (EDIC) and the pre-radiotherapy (RT) absolute lymphocyte count (ALC) to predict lymphopenia during RT, treatment outcomes, and efficacy of consolidation immunotherapy in patients with locally advanced non-small cell lung cancer was investigated.Methods and materials: Among 517 patients treated with concurrent chemoradiotherapy, EDIC was calculated using the mean doses to the lungs, heart, and total body. The patients were grouped according to high and low EDIC and pre-RT ALC, and the correlations with radiation-induced lymphopenia and survival outcomes were determined.Results: Altogether, 195 patients (37.7%) received consolidation immunotherapy. The cutoff values of EDIC and pre-RT ALC for predicting severe lymphopenia were 2.89 Gy and 2.03 x 10(9) cells/L, respectively. The high-risk group was defined as EDIC >= 2.89 Gy and pre-RT ALC < 2.03 x 10(9) cells/L, while the low-risk group as EDIC < 2.89 Gy and pre-RT ALC >= 2.03 x 10(9) cells/L, and the rest of the patients as the intermediate-risk group. The incidences of severe lymphopenia during RT in the high-, intermediate-, and low-risk groups were 90.1%, 77.1%, and 52.3%, respectively (P < 0.001). The risk groups could independently predict both progression-free (P < 0.001) and overall survival (P < 0.001). The high-risk group showed a higher incidence of locoregional and distant recurrence (P < 0.001). Consolidation immunotherapy showed significant survival benefit in the low- and intermediate-risk groups but not in the high-risk group.Conclusions: The combination of EDIC and pre-RT ALC predicted severe lymphopenia, recurrence, and survival. It may potentially serve as a biomarker for consolidation immunotherapy. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.title | Risk of on-treatment lymphopenia is associated with treatment outcome and efficacy of consolidation immunotherapy in patients with non-small cell lung cancer treated with concurrent chemoradiotherapy | - |
dc.type | Article | - |
dc.identifier.wosid | 001096408200001 | - |
dc.identifier.doi | 10.1016/j.radonc.2023.109934 | - |
dc.identifier.bibliographicCitation | RADIOTHERAPY AND ONCOLOGY, v.189 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85173176068 | - |
dc.citation.title | RADIOTHERAPY AND ONCOLOGY | - |
dc.citation.volume | 189 | - |
dc.type.docType | Article | - |
dc.publisher.location | 아일랜드 | - |
dc.subject.keywordAuthor | Lymphopenia | - |
dc.subject.keywordAuthor | Progression-free survival | - |
dc.subject.keywordAuthor | Survival | - |
dc.subject.keywordAuthor | Immunotherapy | - |
dc.subject.keywordAuthor | Carcinoma | - |
dc.subject.keywordAuthor | Non-Small-Cell Lung | - |
dc.subject.keywordAuthor | Chemoradiotherapy | - |
dc.subject.keywordPlus | CARBON-ION RADIOTHERAPY | - |
dc.subject.keywordPlus | RADIATION | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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