Senolytics: Opening avenues in drug discovery to find novel therapeutics for Parkinson's Disease
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kakoty, Violina | - |
dc.contributor.author | Chandran, Sarathlal Kalarikkal | - |
dc.contributor.author | Gulati, Monica | - |
dc.contributor.author | Goh, Bey Hing | - |
dc.contributor.author | Dua, Kamal | - |
dc.contributor.author | Singh, Sachin Kumar | - |
dc.date.accessioned | 2024-07-08T05:00:41Z | - |
dc.date.available | 2024-07-08T05:00:41Z | - |
dc.date.issued | 2023-06 | - |
dc.identifier.issn | 1359-6446 | - |
dc.identifier.issn | 1878-5832 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/91871 | - |
dc.description.abstract | Aging is one of the major risk factors for most neurodegenerative disorders including Parkinson's disease (PD). More than 10 million people are affected with PD worldwide. One of the predominant factors accountable for progression of PD pathology could be enhanced accumulation of senescent cells in the brain with the progress of age. Recent investigations have highlighted that senescent cells can ignite PD pathology via increased oxidative stress and neuroinflammation. Senolytics are agents that kill senescent cells. This review mainly focuses on understanding the pathological connection between senescence and PD, with emphasis on some of the recent advances made in the area of senolytics and their evolution to potential clinical candidates for future pharmaceuticals against PD. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.title | Senolytics: Opening avenues in drug discovery to find novel therapeutics for Parkinson's Disease | - |
dc.type | Article | - |
dc.identifier.wosid | 000984989200001 | - |
dc.identifier.doi | 10.1016/j.drudis.2023.103582 | - |
dc.identifier.bibliographicCitation | DRUG DISCOVERY TODAY, v.28, no.6, pp 1 - 9 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85152897325 | - |
dc.citation.endPage | 9 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | DRUG DISCOVERY TODAY | - |
dc.citation.volume | 28 | - |
dc.citation.number | 6 | - |
dc.type.docType | Review | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Parkinson's disease | - |
dc.subject.keywordAuthor | senolytics | - |
dc.subject.keywordAuthor | senescence | - |
dc.subject.keywordPlus | SENESCENT CELLS | - |
dc.subject.keywordPlus | CELLULAR SENESCENCE | - |
dc.subject.keywordPlus | ALPHA-SYNUCLEIN | - |
dc.subject.keywordPlus | BCL-XL | - |
dc.subject.keywordPlus | MEMBRANE | - |
dc.subject.keywordPlus | BCL-X(L) | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.