Polycyclic aromatic hydrocarbons and changes in brain cortical thickness and an Alzheimer's disease-specific marker for cortical atrophy in adults: A longitudinal neuroimaging study of the EPINEF cohort
DC Field | Value | Language |
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dc.contributor.author | Cho, Jaelim | - |
dc.contributor.author | Sohn, Jungwoo | - |
dc.contributor.author | Yang, Sung Hee | - |
dc.contributor.author | Lee, Seung-Koo | - |
dc.contributor.author | Noh, Young | - |
dc.contributor.author | Oh, Sung Soo | - |
dc.contributor.author | Koh, Sang-Baek | - |
dc.contributor.author | Kim, Changsoo | - |
dc.date.accessioned | 2024-07-08T09:32:28Z | - |
dc.date.available | 2024-07-08T09:32:28Z | - |
dc.date.issued | 2023-10 | - |
dc.identifier.issn | 0045-6535 | - |
dc.identifier.issn | 1879-1298 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/91962 | - |
dc.description.abstract | Although several epidemiological studies have suggested that exposure to polycyclic aromatic hydrocarbons (PAHs) may induce brain atrophy, no longitudinal study has investigated the effect of PAH exposure on brain structural changes. This study examined the longitudinal associations between urinary PAH metabolites and brain cortical thickness. We obtained urinary concentrations of PAH metabolites and brain magnetic resonance images from 327 adults (≥50 years of age) without dementia at baseline and 3-year follow-up. We obtained whole-brain and regional cortical thicknesses, as well as an Alzheimer's disease (AD)-specific marker for cortical atrophy (a higher score indicated a greater similarity to patients with AD) at baseline and follow-up. We built a linear mixed-effect model including each of urinary PAH metabolites as the time-varying exposure variable of interest. We found that increases in urinary concentrations of 1-hydroxypyrene (β = −0.004; 95% CI, −0.008 to −0.001) and 2-hydroxyfluorene (β = −0.011; 95% CI, −0.015 to −0.006) were significantly associated with a reduced whole-brain cortical thickness. A urinary concentration of 2-hydroxyfluorene was significantly associated with an increased AD-specific cortical atrophy score (β = 2.031; 95% CI, 0.512 to 3.550). The specific brain regions showing the association of urinary concentrations of 1-hydroxypyrene, 2-naphthol, 1-hydroxyphenanthrene, or 2-hydroxyfluorene with cortical thinning were the frontal, parietal, temporal, and cingulate lobes. These findings suggested that exposure to PAHs may reduce brain cortical thickness and increase the similarity to AD-specific cortical atrophy patterns in adults. © 2023 Elsevier Ltd | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier Ltd | - |
dc.title | Polycyclic aromatic hydrocarbons and changes in brain cortical thickness and an Alzheimer's disease-specific marker for cortical atrophy in adults: A longitudinal neuroimaging study of the EPINEF cohort | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.chemosphere.2023.139596 | - |
dc.identifier.bibliographicCitation | Chemosphere, v.338 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85165613740 | - |
dc.citation.title | Chemosphere | - |
dc.citation.volume | 338 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Cortical thickness | - |
dc.subject.keywordAuthor | Linear mixed model | - |
dc.subject.keywordAuthor | Neuroimaging | - |
dc.subject.keywordAuthor | Polycyclic aromatic hydrocarbon | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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