Radiofrequency Treatment Attenuates Age-Related Changes in Dermal-Epidermal Junctions of Animal Skin
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Byun, Kyung-A | - |
dc.contributor.author | Kim, Hyoung Moon | - |
dc.contributor.author | Oh, Seyeon | - |
dc.contributor.author | Batsukh, Sosorburam | - |
dc.contributor.author | Son, Kuk Hui | - |
dc.contributor.author | Byun, Kyunghee | - |
dc.date.accessioned | 2024-07-23T11:00:19Z | - |
dc.date.available | 2024-07-23T11:00:19Z | - |
dc.date.issued | 2024-05 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/92059 | - |
dc.description.abstract | The dermal-epidermal junction (DEJ) is essential for maintaining skin structural integrity and regulating cell survival and proliferation. Thus, DEJ rejuvenation is key for skin revitalization, particularly in age-related DEJ deterioration. Radiofrequency (RF) treatment, known for its ability to enhance collagen fiber production through thermal mechanisms and increase heat shock protein (HSP) expression, has emerged as a promising method for skin rejuvenation. Additionally, RF activates Piezo1, an ion channel implicated in macrophage polarization toward an M2 phenotype and enhanced TGF-beta production. This study investigated the impact of RF treatment on HSP47 and HSP90 expression, known stimulators of DEJ protein expression. Furthermore, using in vitro and aged animal skin models, we assessed whether RF-induced Piezo1 activation and the subsequent M2 polarization could counter age-related DEJ changes. The RF treatment of H2O2-induced senescent keratinocytes upregulated the expression of HSP47, HSP90, TGF-beta, and DEJ proteins, including collagen XVII. Similarly, the RF treatment of senescent macrophages increased Piezo1 and CD206 (M2 marker) expression. Conditioned media from RF-treated senescent macrophages enhanced the expression of TGF-beta and DEJ proteins, such as nidogen and collagen IV, in senescent fibroblasts. In aged animal skin, RF treatment increased the expression of HSP47, HSP90, Piezo1, markers associated with M2 polarization, IL-10, and TGF-beta. Additionally, RF treatment enhanced DEJ protein expression. Moreover, RF reduced lamina densa replication, disrupted lesions, promoted hemidesmosome formation, and increased epidermal thickness. Overall, RF treatment effectively enhanced DEJ protein expression and mitigated age-related DEJ structural changes by increasing HSP levels and activating Piezo1. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI | - |
dc.title | Radiofrequency Treatment Attenuates Age-Related Changes in Dermal-Epidermal Junctions of Animal Skin | - |
dc.type | Article | - |
dc.identifier.wosid | 001234325900001 | - |
dc.identifier.doi | 10.3390/ijms25105178 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.25, no.10 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85194217873 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 25 | - |
dc.citation.number | 10 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | aged mice skin | - |
dc.subject.keywordAuthor | bipolar | - |
dc.subject.keywordAuthor | dermal-epidermal junction | - |
dc.subject.keywordAuthor | heat shock protein | - |
dc.subject.keywordAuthor | monopolar | - |
dc.subject.keywordAuthor | Piezo1 | - |
dc.subject.keywordAuthor | radiofrequency | - |
dc.subject.keywordPlus | BASEMENT-MEMBRANE | - |
dc.subject.keywordPlus | COLLAGEN XVII | - |
dc.subject.keywordPlus | TGF-BETA | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | FIBROBLASTS | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | METALLOPROTEINASES | - |
dc.subject.keywordPlus | KERATINOCYTES | - |
dc.subject.keywordPlus | SENESCENCE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.