Regulation of IL-24 in human oral keratinocytes stimulated with Tannerella forsythia
DC Field | Value | Language |
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dc.contributor.author | Ko, Yeon-Kyeong | - |
dc.contributor.author | An, Sun-Jin | - |
dc.contributor.author | Han, Na-Young | - |
dc.contributor.author | Lee, Hookeun | - |
dc.contributor.author | Choi, Bong-Kyu | - |
dc.date.available | 2020-02-27T02:21:34Z | - |
dc.date.created | 2020-02-04 | - |
dc.date.issued | 2019-10 | - |
dc.identifier.issn | 2041-1006 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/924 | - |
dc.description.abstract | Interleukin-24 is a pleiotropic immunoregulatory cytokine and a member of the IL-20R subfamily of the IL-10 family. The aim of this study was to investigate the regulation of IL-24 in the human oral keratinocyte cell line HOK-16B following infection with Tannerella forsythia, a major periodontal pathogen. T. forsythia induced the expression of IL-24 mRNA and the secretion of glycosylated IL-24 in HOK-16B cells. Glycosylation of IL-24 is linked to its solubility and bioavailability. T. forsythia-stimulated reactive oxygen species (ROS) induced the expression of IL-24, which was regulated by IL-6. The ROS inhibitor N-acetylcysteine and MAPK inhibitors significantly reduced the expression of IL-6 and IL-24 induced by T. forsythia. Recombinant human IL-24 significantly enhanced the expression of IL-1 alpha, IL-8, CXCL10, and MCP-1 in HOK-16B cells. Together, these results indicate that ROS, MAPKs, and IL-6 comprise the axis of IL-24 expression in HOK-16B cells stimulated with T. forsythia. Thus, IL-24 may be involved in inflammation in oral keratinocytes. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.relation.isPartOf | MOLECULAR ORAL MICROBIOLOGY | - |
dc.subject | PORPHYROMONAS-GINGIVALIS | - |
dc.subject | ACTIVATION | - |
dc.subject | RECEPTORS | - |
dc.subject | SURFACE | - |
dc.subject | INFLAMMATION | - |
dc.subject | MDA-7/IL-24 | - |
dc.subject | EXPRESSION | - |
dc.subject | MONOCYTES | - |
dc.subject | INFECTION | - |
dc.subject | PROTEIN | - |
dc.title | Regulation of IL-24 in human oral keratinocytes stimulated with Tannerella forsythia | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000481839900001 | - |
dc.identifier.doi | 10.1111/omi.12265 | - |
dc.identifier.bibliographicCitation | MOLECULAR ORAL MICROBIOLOGY, v.34, no.5, pp.209 - 218 | - |
dc.identifier.scopusid | 2-s2.0-85070895509 | - |
dc.citation.endPage | 218 | - |
dc.citation.startPage | 209 | - |
dc.citation.title | MOLECULAR ORAL MICROBIOLOGY | - |
dc.citation.volume | 34 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | Han, Na-Young | - |
dc.contributor.affiliatedAuthor | Lee, Hookeun | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | IL-24 | - |
dc.subject.keywordAuthor | oral keratinocytes | - |
dc.subject.keywordAuthor | periodontal pathogen | - |
dc.subject.keywordAuthor | reactive oxygen species | - |
dc.subject.keywordPlus | PORPHYROMONAS-GINGIVALIS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | RECEPTORS | - |
dc.subject.keywordPlus | SURFACE | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | MDA-7/IL-24 | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MONOCYTES | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.relation.journalResearchArea | Dentistry, Oral Surgery & Medicine | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Dentistry, Oral Surgery & Medicine | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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