Antiemetic efficacy of dexmedetomidine versus dexmedetomidine-dexamethasone combination in patients undergoing breast surgery
- Authors
- Kwak, HyunJeong; Chang, Young Jin; Lee, Kyung Cheon; Jung, Wol Seon; Kwon, Sunkoo; Jo, Youn Yi
- Issue Date
- Oct-2019
- Publisher
- SAGE PUBLICATIONS LTD
- Keywords
- Postoperative nausea and vomiting; dexamethasone; dexmedetomidine; breast surgery; antiemetic; prophylaxis
- Citation
- JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, v.47, no.10, pp.5060 - 5069
- Journal Title
- JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
- Volume
- 47
- Number
- 10
- Start Page
- 5060
- End Page
- 5069
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/926
- DOI
- 10.1177/0300060519872031
- ISSN
- 0300-0605
- Abstract
- Objective To compare the antiemetic efficacy of dexmedetomidine alone versus combined dexmedetomidine-dexamethasone on incidence of postoperative nausea and vomiting (PONV) in patients undergoing breast surgery. Methods A total of 149 patients (aged 20-65 years) were assigned to receive normal saline (control group, n = 50), dexmedetomidine 0.5 mu g/kg (DEX group, n = 49), or a combination of dexmedetomidine 0.5 mu g/kg and dexamethasone 5 mg (dual group, n = 50) at 30 minutes prior to the end of surgery. The primary outcome measure was the incidence of PONV in the post-anesthesia care unit (PACU). Results During the first 24 hours after surgery, the incidence of PONV was significantly higher in the control group than in the DEX and dual groups (70% vs. 20% and 12%, respectively), with no intergroup difference observed between the DEX and dual groups. In the PACU, the incidence of PONV differed significantly among the control, DEX, and dual groups (12%, 4%, and 3%, respectively). Conclusion Dexmedetomidine alone and in combination with dexamethasone significantly reduced PONV with similar antiemetic efficacies in female patients during the first 24 hours after breast surgery.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 의과대학 > 의학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/926)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.