Vascular Contributions in Alzheimer's Disease-Related Neuropathological Changes: First Autopsy Evidence from a South Asian Aging Population
DC Field | Value | Language |
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dc.contributor.author | Wijesinghe, Printha | - |
dc.contributor.author | Shankar, S. K. | - |
dc.contributor.author | Yasha, T. C. | - |
dc.contributor.author | Gorrie, Catherine | - |
dc.contributor.author | Amaratunga, Dhammika | - |
dc.contributor.author | Hulathduwa, Sanjayah | - |
dc.contributor.author | Kumara, K. Sunil | - |
dc.contributor.author | Samarasinghe, Kamani | - |
dc.contributor.author | Suh, Yoo-hun | - |
dc.contributor.author | Steinbusch, Harry W. M. | - |
dc.contributor.author | De Silva, K. Ranil D. | - |
dc.date.available | 2020-02-28T06:43:02Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1387-2877 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/9667 | - |
dc.description.abstract | Background: Evidence from various consortia on vascular contributions has been inconsistent in determining the etiology of sporadic Alzheimer's disease (AD). Objective: To investigate vascular risk factors and cerebrovascular pathologies associated in manifestation of AD-related neuropathological changes of an elderly population. Methods: Postmortem brain samples from 76 elderly subjects (>= 50 years) were used to study genetic polymorphisms, intracranial atherosclerosis of the circle of Willis (IASCW), and microscopic infarcts in deep white matters. From this cohort, 50 brains (>= 60 years) were subjected to neuropathological diagnosis using immunohistopathological techniques. Results: Besides the association with age, the apolipoprotein E epsilon 4 allele was significantly and strongly associated with Thal amyloid-beta phases >= 1 [odds ratio (OR) = 6.76, 95% confidence interval (CI) 1.37-33.45] and inversely with Braak neurofibrillary tangle (NFT) stages >= III (0.02, 0.0-0.47). Illiterates showed a significant positive association for Braak NFT stages >= IV (14.62, 1.21-176.73) and a significant negative association for microscopic infarcts (0.15, 0.03-0.71) in deep white matters. With respect to cerebrovascular pathologies, cerebral small vessel lesions (white matter hyperintensities and cerebral amyloid angiopathy) showed a higher degree of associations among them and with AD-related neuropathological changes (p < 0.05) compared to large vessel pathology (IASCW), which showed a significant association only with Braak NFT stages >= I (p = 0.050). Conclusion: These findings suggest that besides age, education, and genetic factors, other vascular risk factors were not associated with AD-related neuropathological changes and urge prompt actions be taken against cerebral small vessel diseases since evidence for effective prevention is still lacking. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | IOS PRESS | - |
dc.relation.isPartOf | JOURNAL OF ALZHEIMERS DISEASE | - |
dc.subject | RISK-FACTORS | - |
dc.subject | APOLIPOPROTEIN-E | - |
dc.subject | WILLIS ATHEROSCLEROSIS | - |
dc.subject | COGNITIVE IMPAIRMENT | - |
dc.subject | DEMENTIA | - |
dc.subject | PATHOLOGY | - |
dc.subject | ASSOCIATION | - |
dc.subject | AGE | - |
dc.subject | EPIDEMIOLOGY | - |
dc.subject | PATHOPHYSIOLOGY | - |
dc.title | Vascular Contributions in Alzheimer's Disease-Related Neuropathological Changes: First Autopsy Evidence from a South Asian Aging Population | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000386749900029 | - |
dc.identifier.doi | 10.3233/JAD-160425 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ALZHEIMERS DISEASE, v.54, no.4, pp.1607 - 1618 | - |
dc.identifier.scopusid | 2-s2.0-84992152179 | - |
dc.citation.endPage | 1618 | - |
dc.citation.startPage | 1607 | - |
dc.citation.title | JOURNAL OF ALZHEIMERS DISEASE | - |
dc.citation.volume | 54 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Suh, Yoo-hun | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | apolipoprotein E | - |
dc.subject.keywordAuthor | atherosclerosis | - |
dc.subject.keywordAuthor | cerebral small vessel diseases | - |
dc.subject.keywordAuthor | neuropathology | - |
dc.subject.keywordPlus | RISK-FACTORS | - |
dc.subject.keywordPlus | APOLIPOPROTEIN-E | - |
dc.subject.keywordPlus | WILLIS ATHEROSCLEROSIS | - |
dc.subject.keywordPlus | COGNITIVE IMPAIRMENT | - |
dc.subject.keywordPlus | DEMENTIA | - |
dc.subject.keywordPlus | PATHOLOGY | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | AGE | - |
dc.subject.keywordPlus | EPIDEMIOLOGY | - |
dc.subject.keywordPlus | PATHOPHYSIOLOGY | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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