Protective Effect of Psoralea corylifolia L. Seed Extract against Palmitate- Induced Neuronal Apoptosis in PC12 Cells
DC Field | Value | Language |
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dc.contributor.author | Lee, Yunkyoung | - |
dc.contributor.author | Jun, Hee-Sook | - |
dc.contributor.author | Oh, Yoon Sin | - |
dc.date.available | 2020-02-28T06:43:03Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2016-10 | - |
dc.identifier.issn | 1741-427X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/9669 | - |
dc.description.abstract | The extract of Psoralea corylifolia seeds (PCE) has been widely used as a herbal medicine because of its beneficial effect on human health. In this study, we investigated the protective effects and molecular mechanisms of PCE on palmitate-(PA-) induced toxicity in PC12 cells, a neuron-like cell line. PCE significantly increased cell viability in PA-treated PC12 cells and showed antiapoptotic effects, as evidenced by decreased expression of cleaved caspase-3, cleaved poly(ADP-ribose) polymerase, and bax protein as well as increased expression of bcl-2 protein. In addition, PCE treatment reduced PA-induced reactive oxygen species production and upregulated mRNA levels of antioxidant genes such as nuclear factor (erythroid-derived 2)-like 2 and heme oxygenase 1. Moreover, PCE treatment recovered the expression of autophagy marker genes such as beclin-1 and p62, which was decreased by PA treatment. Treatment with isopsoralen, one of the major components of PCE extract, also recovered the expression of autophagy marker genes and reduced PA-induced apoptosis. In conclusion, PCE exerts protective effects against lipotoxicity via its antioxidant function, and this effect is mediated by activation of autophagy. PCE might be a potential pharmacological agent to protect against neuronal cell injury caused by oxidative stress or lipotoxicity. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | HINDAWI LTD | - |
dc.relation.isPartOf | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | - |
dc.title | Protective Effect of Psoralea corylifolia L. Seed Extract against Palmitate- Induced Neuronal Apoptosis in PC12 Cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000387378600001 | - |
dc.identifier.doi | 10.1155/2016/5410419 | - |
dc.identifier.bibliographicCitation | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, v.2016 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-84994571068 | - |
dc.citation.title | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | - |
dc.citation.volume | 2016 | - |
dc.contributor.affiliatedAuthor | Lee, Yunkyoung | - |
dc.contributor.affiliatedAuthor | Jun, Hee-Sook | - |
dc.contributor.affiliatedAuthor | Oh, Yoon Sin | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | INDUCED OXIDATIVE STRESS | - |
dc.subject.keywordPlus | MITOCHONDRIAL DYSFUNCTION | - |
dc.subject.keywordPlus | BASAL AUTOPHAGY | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | DEATH | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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