Affective network and default mode network in depressive adolescents with disruptive behaviors
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Sun Mi | - |
dc.contributor.author | Park, Sung Yong | - |
dc.contributor.author | Kim, Young In | - |
dc.contributor.author | Son, Young Don | - |
dc.contributor.author | Chung, Un-Sun | - |
dc.contributor.author | Min, Kyung Joon | - |
dc.contributor.author | Han, Doug Hyun | - |
dc.date.available | 2020-02-28T06:43:17Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2016-12 | - |
dc.identifier.issn | 1178-2021 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/9689 | - |
dc.description.abstract | Aim: Disruptive behaviors are thought to affect the progress of major depressive disorder (MDD) in adolescents. In resting-state functional connectivity (RSFC) studies of MDD, the affective network (limbic network) and the default mode network (DMN) have garnered a great deal of interest. We aimed to investigate RSFC in a sample of treatment-naive adolescents with MDD and disruptive behaviors. Methods: Twenty-two adolescents with MDD and disruptive behaviors ((disrup)-MDD) and 20 age-and sex-matched healthy control (HC) participants underwent resting-state functional magnetic resonance imaging (fMRI). We used a seed-based correlation approach concerning two brain circuits including the affective network and the DMN, with two seed regions -including the bilateral amygdala for the limbic network and the bilateral posterior cingulate cortex (PCC) for the DMN. We also observed a correlation between RSFC and severity of depressive symptoms and disruptive behaviors. Results: The (disrup)-MDD participants showed lower RSFC from the amygdala to the orbito-frontal cortex and parahippocampal gyrus compared to HC participants. Depression scores in disrup-MDD participants were negatively correlated with RSFC from the amygdala to the right orbitofrontal cortex. The (disrup)-MDD participants had higher PCC RSFC compared to HC participants in a cluster that included the left precentral gyrus, left insula, and left parietal lobe. Disruptive behavior scores in (disrup)-MDD patients were positively correlated with RSFC from the PCC to the left insular cortex. Conclusion: Depressive mood might be correlated with the affective network, and disruptive behavior might be correlated with the DMN in adolescent depression. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | DOVE MEDICAL PRESS LTD | - |
dc.relation.isPartOf | NEUROPSYCHIATRIC DISEASE AND TREATMENT | - |
dc.title | Affective network and default mode network in depressive adolescents with disruptive behaviors | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000367437900001 | - |
dc.identifier.doi | 10.2147/NDT.S95541 | - |
dc.identifier.bibliographicCitation | NEUROPSYCHIATRIC DISEASE AND TREATMENT, v.12, pp.49 - 56 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-84954525102 | - |
dc.citation.endPage | 56 | - |
dc.citation.startPage | 49 | - |
dc.citation.title | NEUROPSYCHIATRIC DISEASE AND TREATMENT | - |
dc.citation.volume | 12 | - |
dc.contributor.affiliatedAuthor | Son, Young Don | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | resting-state functional connectivity | - |
dc.subject.keywordAuthor | major depressive disorder | - |
dc.subject.keywordAuthor | disruptive behaviors | - |
dc.subject.keywordAuthor | limbic network | - |
dc.subject.keywordAuthor | default mode network | - |
dc.subject.keywordPlus | ATTENTION-DEFICIT/HYPERACTIVITY DISORDER | - |
dc.subject.keywordPlus | STATE FUNCTIONAL CONNECTIVITY | - |
dc.subject.keywordPlus | PREFRONTAL CORTEX | - |
dc.subject.keywordPlus | AMYGDALA RESPONSE | - |
dc.subject.keywordPlus | CONDUCT DISORDER | - |
dc.subject.keywordPlus | EMOTIONAL FACES | - |
dc.subject.keywordPlus | CIRCUITRY | - |
dc.subject.keywordPlus | PATTERNS | - |
dc.subject.keywordPlus | ORGANIZATION | - |
dc.subject.keywordPlus | RECRUITMENT | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.