Design, synthesis and anti-proliferative activities of novel 7 '-O-substituted schisantherin A derivatives
DC Field | Value | Language |
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dc.contributor.author | Venkanna, A. | - |
dc.contributor.author | Kumar, Ch. Pavan | - |
dc.contributor.author | Poornima, B. | - |
dc.contributor.author | Siva, Bandi | - |
dc.contributor.author | Jain, Nishant | - |
dc.contributor.author | Babu, K. Suresh | - |
dc.date.available | 2020-02-28T06:43:51Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 2040-2503 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/9730 | - |
dc.description.abstract | A series of schisantherin A (1) derivatives were efficiently synthesized utilizing Yamaguchi esterification (2,4,6-trichlorobenzoyl chloride, Et3N, THF, DMAP, toluene) at the C-7'position of the schisantherin A core. The synthesized derivatives were evaluated for their anti-cancer activities against SIHA, PANC 1, MDA-MB-231, IMR-32, DU-145 and A549 cancer cell lines using sulforhodamine B assay. Within the new series tested, compound 29 displayed the most promising cytotoxic effect against the human cervical cancer cell line (SIHA) with a GI(50) value of < 0.01 mu M, which is comparable to that of the standard drug, doxorubicin. Mechanism of action studies validated that 29 functions as a microtubule inhibitor. Additionally, several of the other analogues exhibited potent activity against the tested cell lines. Based on the results obtained, structure-activity relationships (SARs) were established and a correlation between the activities was also observed and discussed. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.relation.isPartOf | MEDCHEMCOMM | - |
dc.subject | SCHIZANDRA-CHINENSIS BAILL | - |
dc.subject | NATURAL-PRODUCTS | - |
dc.subject | SCHISANDRA-CHINENSIS | - |
dc.subject | ABSOLUTE STRUCTURE | - |
dc.subject | GOMISIN-A | - |
dc.subject | LIGNANS | - |
dc.subject | CONSTITUENTS | - |
dc.title | Design, synthesis and anti-proliferative activities of novel 7 '-O-substituted schisantherin A derivatives | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000378246000013 | - |
dc.identifier.doi | 10.1039/c6md00097e | - |
dc.identifier.bibliographicCitation | MEDCHEMCOMM, v.7, no.6, pp.1159 - 1170 | - |
dc.citation.endPage | 1170 | - |
dc.citation.startPage | 1159 | - |
dc.citation.title | MEDCHEMCOMM | - |
dc.citation.volume | 7 | - |
dc.citation.number | 6 | - |
dc.contributor.affiliatedAuthor | Venkanna, A. | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | SCHIZANDRA-CHINENSIS BAILL | - |
dc.subject.keywordPlus | NATURAL-PRODUCTS | - |
dc.subject.keywordPlus | SCHISANDRA-CHINENSIS | - |
dc.subject.keywordPlus | ABSOLUTE STRUCTURE | - |
dc.subject.keywordPlus | GOMISIN-A | - |
dc.subject.keywordPlus | LIGNANS | - |
dc.subject.keywordPlus | CONSTITUENTS | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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