Introduction to cerebral cavernous malformation: a brief review
DC Field | Value | Language |
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dc.contributor.author | Kim, Jaehong | - |
dc.date.available | 2020-02-28T06:44:10Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2016-05 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/9754 | - |
dc.description.abstract | The disease known as cerebral cavernous malformations mostly occurs in the central nervous system, and their typical histological presentations are multiple lumen formation and vascular leakage at the brain capillary level, resulting in disruption of the blood-brain barrier. These abnormalities result in severe neurological symptoms such as seizures, focal neurological deficits and hemorrhagic strokes. CCM research has identified 'loss of function' mutations of three ccm genes responsible for the disease and also complex regulation of multiple signaling pathways including the WNT/beta-catenin pathway, TGF-beta and Notch signaling by the ccm genes. Although CCM research is a relatively new and small scientific field, as CCM research has the potential to regulate systemic blood vessel permeability and angiogenesis including that of the blood-brain barrier, this field is growing rapidly. In this review, I will provide a brief overview of CCM pathogenesis and function of ccm genes based on recent progress in CCM research. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY | - |
dc.relation.isPartOf | BMB REPORTS | - |
dc.title | Introduction to cerebral cavernous malformation: a brief review | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000383786500004 | - |
dc.identifier.doi | 10.5483/BMBRep.2016.49.5.036 | - |
dc.identifier.bibliographicCitation | BMB REPORTS, v.49, no.5, pp.255 - 262 | - |
dc.identifier.kciid | ART002109527 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-84969915377 | - |
dc.citation.endPage | 262 | - |
dc.citation.startPage | 255 | - |
dc.citation.title | BMB REPORTS | - |
dc.citation.volume | 49 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | Kim, Jaehong | - |
dc.type.docType | Review | - |
dc.subject.keywordAuthor | Angiogenesis | - |
dc.subject.keywordAuthor | Central nervous system | - |
dc.subject.keywordAuthor | Cerebral cavernous malformation | - |
dc.subject.keywordAuthor | Signaling | - |
dc.subject.keywordAuthor | Vascular permeability | - |
dc.subject.keywordPlus | IN-FRAME DELETION | - |
dc.subject.keywordPlus | TRAPPED 1 KRIT1 | - |
dc.subject.keywordPlus | VASCULAR-PERMEABILITY | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | ITALIAN PATIENTS | - |
dc.subject.keywordPlus | STRUCTURAL BASIS | - |
dc.subject.keywordPlus | GCKIII PROTEINS | - |
dc.subject.keywordPlus | RHO KINASE | - |
dc.subject.keywordPlus | CCM3 | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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