Relationships between [F-18]-THK5351 Retention and Language Functions in Primary Progressive Aphasia
DC Field | Value | Language |
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dc.contributor.author | Jeong, Hye Jin | - |
dc.contributor.author | Yoon, Cindy W. | - |
dc.contributor.author | Seo, Seongho | - |
dc.contributor.author | Lee, Sang-Yoon | - |
dc.contributor.author | Suh, Mee Kyung | - |
dc.contributor.author | Seo, Ha-Eun | - |
dc.contributor.author | Kim, Woo-Ram | - |
dc.contributor.author | Lee, Hyon | - |
dc.contributor.author | Heo, Jae-Hyeok | - |
dc.contributor.author | Lee, Yeong-Bae | - |
dc.contributor.author | Park, Kee Hyung | - |
dc.contributor.author | Choi, Seong Hye | - |
dc.contributor.author | Ido, Tatsuo | - |
dc.contributor.author | Lee, Kyoung-Min | - |
dc.contributor.author | Noh, Young | - |
dc.date.available | 2020-02-27T02:22:00Z | - |
dc.date.created | 2020-02-04 | - |
dc.date.issued | 2019-10 | - |
dc.identifier.issn | 1738-6586 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/975 | - |
dc.description.abstract | Background and Purpose There are three distinct subtypes of primary progressive aphasia (PPA): the nonfluent/agrammatic variant (nfvPPA), the semantic variant (svPPA), and the logopenic variant (lvPPA). We sought to characterize the pattern of [F-18]-THK5351 retention across all three subtypes and determine the topography of [F-18]-THK5351 retention correlated with each neurolinguistic score. Methods We enrolled 50 participants, comprising 13 PPA patients (3 nfvPPA, 5 svPPA, and 5 lvPPA) and 37 subjects with normal cognition (NC) who underwent 3.0-tesla magnetic resonance imaging, [F-18]-THK5351 positron-emission tomography scans, and detailed neuropsychological tests. The PPA patients additionally participated in extensive neurolinguistic tests. Voxel-wise and region-of-interest-based analyses were performed to analyze [F-18]-THK5351 retention. Results The nfvPPA patients exhibited higher [F-18]-THK5351 retention in the the left inferior frontal and precentral gyri. In svPPA patients, [F-18]-THK5351 retention was elevated in the anteroinferior and lateral temporal cortices compared to the NC group (left>right). The lvPPA patients exhibited predominant [F-18]-THK5351 retention in the inferior parietal, lateral temporal, and dorsolateral prefrontal cortices, and the precuneus (left>right). [F-18]-THK5351 retention in the left inferior frontal area was associated with lower fluency scores. Comprehension was correlated with [F-18]-THK5351 retention in the left temporal cortices. Repetition was associated with [F-18]-THK5351 retention in the left inferior parietal and posterior temporal areas, while naming difficulty was correlated with retention in the left fusiform and temporal cortices. Conclusions The pattern of [F-18]-THK5351 retention was well matched with clinical and radiological findings for each PPA subtype, in agreement with the anatomical and functional location of each language domain. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN NEUROLOGICAL ASSOC | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL NEUROLOGY | - |
dc.title | Relationships between [F-18]-THK5351 Retention and Language Functions in Primary Progressive Aphasia | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000491217300014 | - |
dc.identifier.doi | 10.3988/jcn.2019.15.4.527 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL NEUROLOGY, v.15, no.4, pp.527 - 536 | - |
dc.identifier.kciid | ART002510575 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85075461775 | - |
dc.citation.endPage | 536 | - |
dc.citation.startPage | 527 | - |
dc.citation.title | JOURNAL OF CLINICAL NEUROLOGY | - |
dc.citation.volume | 15 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Jeong, Hye Jin | - |
dc.contributor.affiliatedAuthor | Seo, Seongho | - |
dc.contributor.affiliatedAuthor | Lee, Sang-Yoon | - |
dc.contributor.affiliatedAuthor | Seo, Ha-Eun | - |
dc.contributor.affiliatedAuthor | Kim, Woo-Ram | - |
dc.contributor.affiliatedAuthor | Lee, Hyon | - |
dc.contributor.affiliatedAuthor | Lee, Yeong-Bae | - |
dc.contributor.affiliatedAuthor | Park, Kee Hyung | - |
dc.contributor.affiliatedAuthor | Ido, Tatsuo | - |
dc.contributor.affiliatedAuthor | Noh, Young | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | primary progressive aphasia | - |
dc.subject.keywordAuthor | neurofibrillary tangles | - |
dc.subject.keywordAuthor | positron-emission tomography | - |
dc.subject.keywordAuthor | language | - |
dc.subject.keywordPlus | NEUROFIBRILLARY PATHOLOGY | - |
dc.subject.keywordPlus | TAU | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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