Prunus mume leaf extract lowers blood glucose level in diabetic mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Min Woo | - |
dc.contributor.author | Kwon, Jung Eun | - |
dc.contributor.author | Lee, Young-Jong | - |
dc.contributor.author | Jeong, Yong Joon | - |
dc.contributor.author | Kim, Inhye | - |
dc.contributor.author | Cho, Young Mi | - |
dc.contributor.author | Kim, Yong-Min | - |
dc.contributor.author | Kang, Se Chan | - |
dc.date.available | 2020-02-28T06:44:17Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1388-0209 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/9761 | - |
dc.description.abstract | Context Diabetes is a common metabolic disease with long-term complications. Prunus mume Sieb. et Zucc. (Rosaceae) fruits have shown to ameliorate glucose intolerance. However, the antidiabetic effects of P. mume leaves have not been investigated. Objective This study evaluated the effects of P. mume leaf 70% ethanol extract (PMLE) on alleviating diabetes in vivo and in vitro. Materials and methods PMLE was fractionated into n-hexane, dichloromethane (CH2Cl2), ethyl acetate (EtOAc), n-butanol (BuOH) and water. Polyphenol and flavonoid contents in PMLE fractions were determined using Folin-Ciocalteu reagent and the aluminium chloride colorimetric method, respectively. We evaluated alpha-glucosidase inhibition using a microplate reader at 400 nm. Adipocyte differentiation by lipid accumulation was measured using Nile Red staining. Male imprinting control region (ICR) mice were injected with streptozotocin (STZ, 100 mg/kg, i. p.). High-fat diets were provided for three weeks prior to PMLE treatments to induce type 2 diabetes. PMLE (0, 5, 25 or 50 mg/kg) was administrated for four weeks with high-fat diets. Results The EtOAc fraction of PMLE inhibited alpha-glucosidase activity (IC50 = 68.2 mu g/mL) and contained 883.5 +/- 14.9 mg/g of polyphenols and 820.1 +/- 7.7 mg/g of flavonoids. The 50 mg/kg PMLE supplement reduced 40% of blood glucose level compared to obese/diabetes mice. Obese/diabetic mice treated with 50 mg/kg PMLE showed a lower level of triacylglycerol (320.7 +/- 20.73 mg/dL) compared to obese/diabetes mice (494.9 +/- 14.80 mg/dL). Conclusion The data demonstrate that P. mume leaves exert antidiabetic effects that may be attributable to high concentrations of polyphenols and flavonoids. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.relation.isPartOf | PHARMACEUTICAL BIOLOGY | - |
dc.subject | PPAR-GAMMA | - |
dc.subject | INSULIN-RESISTANCE | - |
dc.subject | MELLITUS | - |
dc.subject | THIAZOLIDINEDIONES | - |
dc.subject | AGONISTS | - |
dc.subject | OBESITY | - |
dc.subject | MUSCLE | - |
dc.subject | FRUIT | - |
dc.subject | PLUM | - |
dc.subject | FAT | - |
dc.title | Prunus mume leaf extract lowers blood glucose level in diabetic mice | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000386041500022 | - |
dc.identifier.doi | 10.3109/13880209.2016.1147052 | - |
dc.identifier.bibliographicCitation | PHARMACEUTICAL BIOLOGY, v.54, no.10, pp.2135 - 2140 | - |
dc.identifier.scopusid | 2-s2.0-84959051334 | - |
dc.citation.endPage | 2140 | - |
dc.citation.startPage | 2135 | - |
dc.citation.title | PHARMACEUTICAL BIOLOGY | - |
dc.citation.volume | 54 | - |
dc.citation.number | 10 | - |
dc.contributor.affiliatedAuthor | Lee, Min Woo | - |
dc.contributor.affiliatedAuthor | Lee, Young-Jong | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Adipocyte differentiation | - |
dc.subject.keywordAuthor | flavonoid | - |
dc.subject.keywordAuthor | alpha-glucosidase inhibitor | - |
dc.subject.keywordAuthor | polyphenol | - |
dc.subject.keywordPlus | PPAR-GAMMA | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | MELLITUS | - |
dc.subject.keywordPlus | THIAZOLIDINEDIONES | - |
dc.subject.keywordPlus | AGONISTS | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | MUSCLE | - |
dc.subject.keywordPlus | FRUIT | - |
dc.subject.keywordPlus | PLUM | - |
dc.subject.keywordPlus | FAT | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Medical Laboratory Technology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Medical Laboratory Technology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.