Association between tumor necrosis factor-alpha (TNF-alpha) polymorphism (-308, G/A) and acute rejection of solid organ allograft: a meta-analysis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Sang-Kyu | - |
dc.contributor.author | Kim, Su-Kang | - |
dc.contributor.author | Kang, Sang-Wook | - |
dc.contributor.author | Kim, Bo-Kyun | - |
dc.contributor.author | Chung, Joo-Ho | - |
dc.contributor.author | Park, Min-Su | - |
dc.date.available | 2020-02-28T06:44:18Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1940-5901 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/9763 | - |
dc.description.abstract | The association between gene polymorphisms of tumor necrosis factor-alpha (TNF-alpha) and risk of acute rejection (AR) of solid organ allograft was investigated in many published studies; however, the currently available results are inconclusive. Therefore, we performed a meta-analysis to provide a precise evidence for an association between the TNF-alpha polymorphism and risk of AR. A comprehensive electronic search of PUBMED, EMBASE, scholar of google, and Korean databases was performed until June 1, 2015. Meta-analysis was performed using the comprehensive meta-analysis software (Corporation, NJ, USA). The pooled p value, OR and 95% CI were used to measure the strength of the association with TNF-alpha. Forty five eligible studies were included in this meta-analysis. Our study revealed that combined genotype (A/A genotype + A/G genotype) was contributed to susceptibility of AR in solid organ recipients (OR = 1.424, 95% CI = 1.118-1.813, P = 0.004). Moreover, the Egger's test showed quantitative evidence for absence of publication bias (P = 0.149). This meta-analysis indicated the TNF-a polymorphism (-308, G/A) might be genetic risk factors for acute rejection. However, more studies with larger sample size were needed to provide more precise evidence. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | E-CENTURY PUBLISHING CORP | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | - |
dc.subject | CYTOKINE GENE POLYMORPHISMS | - |
dc.subject | LIVER-TRANSPLANT RECIPIENTS | - |
dc.subject | SINGLE NUCLEOTIDE POLYMORPHISMS | - |
dc.subject | RENAL-ALLOGRAFT | - |
dc.subject | KIDNEY-TRANSPLANTATION | - |
dc.subject | GRAFT-REJECTION | - |
dc.subject | PROMOTER POLYMORPHISMS | - |
dc.subject | TRANSFORMING GROWTH-FACTOR-BETA-1 | - |
dc.subject | CARDIAC ALLOGRAFT | - |
dc.subject | IMMUNE-RESPONSE | - |
dc.title | Association between tumor necrosis factor-alpha (TNF-alpha) polymorphism (-308, G/A) and acute rejection of solid organ allograft: a meta-analysis | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000386671100005 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, v.9, no.9, pp.17060 - 17068 | - |
dc.identifier.scopusid | 2-s2.0-84989183260 | - |
dc.citation.endPage | 17068 | - |
dc.citation.startPage | 17060 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | - |
dc.citation.volume | 9 | - |
dc.citation.number | 9 | - |
dc.contributor.affiliatedAuthor | Park, Sang-Kyu | - |
dc.type.docType | Review | - |
dc.subject.keywordAuthor | Tumor necrosis factor-alpha | - |
dc.subject.keywordAuthor | polymorphism | - |
dc.subject.keywordAuthor | acute rejection | - |
dc.subject.keywordAuthor | meta-analysis | - |
dc.subject.keywordPlus | CYTOKINE GENE POLYMORPHISMS | - |
dc.subject.keywordPlus | LIVER-TRANSPLANT RECIPIENTS | - |
dc.subject.keywordPlus | SINGLE NUCLEOTIDE POLYMORPHISMS | - |
dc.subject.keywordPlus | RENAL-ALLOGRAFT | - |
dc.subject.keywordPlus | KIDNEY-TRANSPLANTATION | - |
dc.subject.keywordPlus | GRAFT-REJECTION | - |
dc.subject.keywordPlus | PROMOTER POLYMORPHISMS | - |
dc.subject.keywordPlus | TRANSFORMING GROWTH-FACTOR-BETA-1 | - |
dc.subject.keywordPlus | CARDIAC ALLOGRAFT | - |
dc.subject.keywordPlus | IMMUNE-RESPONSE | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.