Factors Influencing Clinicians' Choice of Adjuvant S-1 versus Capecitabine plus Oxaliplatin after Curative Gastrectomy in Patients with Gastric Cancer
- Authors
- Lee, Ha Yeon; Hwang, In Gyu; Park, Song-Ee; Kim, Moon Jin; Park, Se Hoon; Kang, Jung Hun; Kim, Young Saing; Oh, Sung Yong; Won, Young-Woong; Lee, Soon Il; Ji, Jun Ho; Chi, Kyong-Choun
- Issue Date
- 2016
- Publisher
- IVYSPRING INT PUBL
- Keywords
- stomach neoplasms; chemotherapy; adjuvant; gastrectomy
- Citation
- JOURNAL OF CANCER, v.7, no.12, pp.1711 - 1715
- Journal Title
- JOURNAL OF CANCER
- Volume
- 7
- Number
- 12
- Start Page
- 1711
- End Page
- 1715
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/9780
- DOI
- 10.7150/jca.15598
- ISSN
- 1837-9664
- Abstract
- Purpose: Two recent randomized, phase III trials in Asia (ACTS-GC and CLASSIC) documented the survival benefit of postoperative chemotherapy after D2 lymph node dissection in patients with gastric cancer. We sought to determine what factors influenced clinicians' choices of either S-1 or capecitabine plus oxaliplatin (CAPOX) as adjuvant therapy after curative D2 gastrectomy. Materials and Methods: We retrospectively reviewed the clinicopathologic factors and adjuvant treatments for 435 patients from nine centers in Korea who were treated with either S-1 or CAPOX adjuvant chemotherapy after undergoing curative D2 gastrectomy between January 2013 and July 2014. Results: Of the 435 patients, 204 (46.9%) were treated with S-1 and 231 (53.1%) were treated with CAPOX. The median age at diagnosis was 61 years (range, 30-88). CAPOX was prescribed more often for patients who were 65 years of age or younger than for patients who were age 65 or older (77.1% vs. 22.9%, P<0.0001). Of the patients in stage II, 121 (60.8%) were treated with S-1 and 78 (39.2%) were given CAPOX; however, of those in stage III, 83 (35.2%) received S-1 and 153 (64.8%) were treated with CAPOX (P<0.0001). Conclusions: Clinicians only preferred CAPOX for younger patients with stage III gastric cancer after curative D2 gastrectomy. However, for elderly patients, clinicians more chose S-1 regardless of the stage.
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