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Synthesis of apoptotic chalcone analogues in HepG2 human hepatocellular carcinoma cells
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Park, Cheon-Soo | - |
| dc.contributor.author | Ahn, Yongchel | - |
| dc.contributor.author | Lee, Dahae | - |
| dc.contributor.author | Moon, Sung Won | - |
| dc.contributor.author | Kim, Ki Hyun | - |
| dc.contributor.author | Yamabe, Noriko | - |
| dc.contributor.author | Hwang, Gwi Seo | - |
| dc.contributor.author | Jang, Hyuk Jai | - |
| dc.contributor.author | Lee, Heesu | - |
| dc.contributor.author | Kang, Ki Sung | - |
| dc.contributor.author | Lee, Jae Wook | - |
| dc.date.available | 2020-02-28T06:45:05Z | - |
| dc.date.created | 2020-02-06 | - |
| dc.date.issued | 2015-12-15 | - |
| dc.identifier.issn | 0960-894X | - |
| dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/9815 | - |
| dc.description.abstract | Eight chalcone analogues were prepared and evaluated for their cytotoxic effects in human hepatoma HepG2 cells. Compound 5 had a potent cytotoxic effect. The percentage of apoptotic cells was significantly higher in compound 5-treated cells than in control cells. Exposure to compound 5 for 24 h induced cleavage of caspase-8 and -3, and poly (ADP-ribose) polymerase (PARP). Our findings suggest that compound 5 is the active chalcone analogue that contributes to cell death in HepG2 cells via the extrinsic apoptotic pathway. (C) 2015 Elsevier Ltd. All rights reserved. | - |
| dc.language | 영어 | - |
| dc.language.iso | en | - |
| dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
| dc.relation.isPartOf | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
| dc.subject | BIOLOGICAL EVALUATION | - |
| dc.subject | DERIVATIVES | - |
| dc.title | Synthesis of apoptotic chalcone analogues in HepG2 human hepatocellular carcinoma cells | - |
| dc.type | Article | - |
| dc.type.rims | ART | - |
| dc.description.journalClass | 1 | - |
| dc.identifier.wosid | 000365032800009 | - |
| dc.identifier.doi | 10.1016/j.bmcl.2015.10.093 | - |
| dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.25, no.24, pp.5705 - 5707 | - |
| dc.identifier.scopusid | 2-s2.0-84947280056 | - |
| dc.citation.endPage | 5707 | - |
| dc.citation.startPage | 5705 | - |
| dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
| dc.citation.volume | 25 | - |
| dc.citation.number | 24 | - |
| dc.contributor.affiliatedAuthor | Lee, Dahae | - |
| dc.contributor.affiliatedAuthor | Yamabe, Noriko | - |
| dc.contributor.affiliatedAuthor | Hwang, Gwi Seo | - |
| dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
| dc.type.docType | Article | - |
| dc.subject.keywordAuthor | Chalcone | - |
| dc.subject.keywordAuthor | Anticancer | - |
| dc.subject.keywordAuthor | HepG2 | - |
| dc.subject.keywordAuthor | Apoptosis | - |
| dc.subject.keywordPlus | BIOLOGICAL EVALUATION | - |
| dc.subject.keywordPlus | DERIVATIVES | - |
| dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
| dc.relation.journalResearchArea | Chemistry | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
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Related Researcher
- Kang, Ki Sung
- College of Korean Medicine (Premedical course of Oriental Medicine)