Comparative assessment of parametric neuroreceptor mapping approaches based on the simplified reference tissue model using [C-11]ABP688 PET
DC Field | Value | Language |
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dc.contributor.author | Seo, Seongho | - |
dc.contributor.author | Kim, Su J. | - |
dc.contributor.author | Kim, Yu K. | - |
dc.contributor.author | Lee, Jee-Young | - |
dc.contributor.author | Jeong, Jae M. | - |
dc.contributor.author | Lee, Dong S. | - |
dc.contributor.author | Lee, Jae S. | - |
dc.date.available | 2020-02-28T07:41:38Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-12 | - |
dc.identifier.issn | 0271-678X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/9855 | - |
dc.description.abstract | In recent years, several linearized model approaches for fast and reliable parametric neuroreceptor mapping based on dynamic nuclear imaging have been developed from the simplified reference tissue model (SRTM) equation. All the methods share the basic SRTM assumptions, but use different schemes to alleviate the effect of noise in dynamic-image voxels. Thus, this study aimed to compare those approaches in terms of their performance in parametric image generation. We used the basis function method and MRTM2 (multilinear reference tissue model with two parameters), which require a division process to obtain the distribution volume ratio (DVR). In addition, a linear model with the DVR as a model parameter (multilinear SRTM) was used in two forms: one based on linear least squares and the other based on extension of total least squares (TLS). Assessment using simulated and actual dynamic [C-11]ABP688 positron emission tomography data revealed their equivalence with the SRTM, except for different noise susceptibilities. In the DVR image production, the two multilinear SRTM approaches achieved better image quality and regional compatibility with the SRTM than the others, with slightly better performance in the TLS-based method. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.relation.isPartOf | JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | - |
dc.subject | GLUTAMATE-RECEPTOR SUBTYPE-5 | - |
dc.subject | POSITRON-EMISSION-TOMOGRAPHY | - |
dc.subject | DYNAMIC PET | - |
dc.subject | GRAPHICAL ANALYSIS | - |
dc.subject | IN-VIVO | - |
dc.subject | RADIOLIGAND BINDING | - |
dc.subject | LINEAR-REGRESSION | - |
dc.subject | C-11-ABP688 | - |
dc.subject | MGLUR5 | - |
dc.subject | LIGAND | - |
dc.title | Comparative assessment of parametric neuroreceptor mapping approaches based on the simplified reference tissue model using [C-11]ABP688 PET | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000365891300022 | - |
dc.identifier.doi | 10.1038/jcbfm.2015.190 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, v.35, no.12, pp.2098 - 2108 | - |
dc.identifier.scopusid | 2-s2.0-84948713359 | - |
dc.citation.endPage | 2108 | - |
dc.citation.startPage | 2098 | - |
dc.citation.title | JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | - |
dc.citation.volume | 35 | - |
dc.citation.number | 12 | - |
dc.contributor.affiliatedAuthor | Kim, Su J. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | neuroreceptor imaging | - |
dc.subject.keywordAuthor | parametric image | - |
dc.subject.keywordAuthor | simplified reference tissue model | - |
dc.subject.keywordAuthor | total least squares | - |
dc.subject.keywordAuthor | tracer kinetic modeling | - |
dc.subject.keywordPlus | GLUTAMATE-RECEPTOR SUBTYPE-5 | - |
dc.subject.keywordPlus | POSITRON-EMISSION-TOMOGRAPHY | - |
dc.subject.keywordPlus | DYNAMIC PET | - |
dc.subject.keywordPlus | GRAPHICAL ANALYSIS | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | RADIOLIGAND BINDING | - |
dc.subject.keywordPlus | LINEAR-REGRESSION | - |
dc.subject.keywordPlus | C-11-ABP688 | - |
dc.subject.keywordPlus | MGLUR5 | - |
dc.subject.keywordPlus | LIGAND | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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