In-vitro cytotoxicity assessment of carbon-nanodot-conjugated Fe-aminoclay (CD-FeAC) and its bio-imaging applications
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, Kyoung Suk | - |
dc.contributor.author | Lee, Hyun Uk | - |
dc.contributor.author | Kim, Moon Il | - |
dc.contributor.author | Park, So Young | - |
dc.contributor.author | Chang, Sung-Jin | - |
dc.contributor.author | Park, Ji-Ho | - |
dc.contributor.author | Huh, Yun Suk | - |
dc.contributor.author | Lee, Jouhahn | - |
dc.contributor.author | Yang, Mino | - |
dc.contributor.author | Lee, Young-Chul | - |
dc.contributor.author | Park, Hyun Gyu | - |
dc.date.available | 2020-02-28T07:42:49Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-11-26 | - |
dc.identifier.issn | 1477-3155 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/9920 | - |
dc.description.abstract | We have investigated the cytotoxic assay of Fe-aminoclay (FeAC) nanoparticles (NPs) and simultaneous imaging in HeLa cells by photoluminescent carbon nanodots (CD) conjugation. Non-cytotoxic, photostable, and CD NPs are conjugated with cationic FeAC NPs where CD NPs play a role in bio-imaging and FeAC NPs act as a substrate for CD conjugation and help to uptake of NPs into cancer cells due to positively charged surface of FeAC NPs in physiological media. As increase of CD-FeAC NPs loading in HeLa cell in vitro, it showed slight cytotoxicity at 1000 mu g/mL but no cytotoxicity for normal cells up to concentration of 1000 mu g/mL confirmed by two 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and neutral red (NR) assays, with further observations by 4', 6-diamidino-2-phenylindole (DAPI) stained confocal microscopy images, possessing that CD-FeAC NPs can be used as potential drug delivery platforms in cancer cells with simultaneous imaging. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | BMC | - |
dc.relation.isPartOf | JOURNAL OF NANOBIOTECHNOLOGY | - |
dc.subject | ORGANO-BUILDING BLOCKS | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | GENE DELIVERY | - |
dc.subject | BIOMEDICAL APPLICATIONS | - |
dc.subject | NANOPARTICLES | - |
dc.subject | CELLS | - |
dc.subject | TRANSFECTION | - |
dc.subject | CANCER | - |
dc.subject | NANOTUBES | - |
dc.subject | TRACKING | - |
dc.title | In-vitro cytotoxicity assessment of carbon-nanodot-conjugated Fe-aminoclay (CD-FeAC) and its bio-imaging applications | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000365339800001 | - |
dc.identifier.doi | 10.1186/s12951-015-0151-z | - |
dc.identifier.bibliographicCitation | JOURNAL OF NANOBIOTECHNOLOGY, v.13 | - |
dc.identifier.scopusid | 2-s2.0-84947901262 | - |
dc.citation.title | JOURNAL OF NANOBIOTECHNOLOGY | - |
dc.citation.volume | 13 | - |
dc.contributor.affiliatedAuthor | Kim, Moon Il | - |
dc.contributor.affiliatedAuthor | Lee, Young-Chul | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | In-vitro cytotoxicity | - |
dc.subject.keywordAuthor | Fe-aminoclay (FeAC) | - |
dc.subject.keywordAuthor | Carbon nanodots (CD) | - |
dc.subject.keywordAuthor | Cytotoxicity | - |
dc.subject.keywordAuthor | Conjugation | - |
dc.subject.keywordAuthor | Bio-imaging | - |
dc.subject.keywordPlus | ORGANO-BUILDING BLOCKS | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | GENE DELIVERY | - |
dc.subject.keywordPlus | BIOMEDICAL APPLICATIONS | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | TRANSFECTION | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | NANOTUBES | - |
dc.subject.keywordPlus | TRACKING | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.