Novel self-micellizing anticancer lipid nanoparticles induce cell death of colorectal cancer cells
DC Field | Value | Language |
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dc.contributor.author | Sundaramoorthy, Pasupathi | - |
dc.contributor.author | Baskaran, Rengarajan | - |
dc.contributor.author | Mishra, Siddhartha Kumar | - |
dc.contributor.author | Jeong, Keun-Yeong | - |
dc.contributor.author | Oh, Seung Hyun | - |
dc.contributor.author | Yoo, Bong Kyu | - |
dc.contributor.author | Kim, Hwan Mook | - |
dc.date.available | 2020-02-28T07:43:16Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-11-01 | - |
dc.identifier.issn | 0927-7765 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/9948 | - |
dc.description.abstract | In the present study, we developed a novel drug-like self-micellizing anticancer lipid (SMAL), and investigated its anticancer activity and effects on cell death pathways in human colorectal cancer (CRC) cell lines.-Three self-assembled nanoparticles were prepared, namely, SMAL102 (lauramide derivative), SMAL104 (palmitamide derivative), and SMAL108 (stearamide derivative) by a thin-film hydration technique, and were characterized for physicochemical and biological parameters. SMAL102 were nanosized (160.23 +/- 8.11 nm) with uniform spherical shape, while SMAL104 and SMAL108 did not form spherical shape but formed large size nanoparticles and irregular in shape. Importantly, SMAL102 showed a cytotoxic effect towards CRC cell lines (HCT116 and HT-29), and less toxicity to a normal colon fibroblast cell line (CCD-18Co). Conversely, SMAL104 and SMAL108 did not have an anti-proliferative effect on CRC cell lines. SMAL102 nanoparticles were actively taken up by CRC cell lines, localized in the cell membrane, and exhibited remarkable cytotoxicity in a concentration-dependent manner. The normal colon cell line showed significantly less cellular uptake and non-cytotoxicity as compared with the CRC cell lines. SMAL102 nanoparticles induced caspase-3, caspase-9, and PARP cleavage in HT-29 cells, indicating the induction of apoptosis; whereas LOB was activated in HCT116 cells, indicating autophagy-induced cell death. Collectively, these results demonstrate that SMAL102 induced cell death via activation of apoptosis and autophagy in CRC cell lines. The present study could be a pioneer for further preclinical and clinical development of such compounds. (c) 2015 Elsevier B.V. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.relation.isPartOf | COLLOIDS AND SURFACES B-BIOINTERFACES | - |
dc.subject | LIPOSOMAL NANOPARTICLES | - |
dc.subject | ANTITUMOR EFFICACY | - |
dc.subject | DELIVERY | - |
dc.subject | THERAPY | - |
dc.subject | CHEMOTHERAPY | - |
dc.subject | PLATFORM | - |
dc.subject | SPHINGOLIPIDS | - |
dc.subject | IRINOTECAN | - |
dc.subject | RESISTANCE | - |
dc.subject | APOPTOSIS | - |
dc.title | Novel self-micellizing anticancer lipid nanoparticles induce cell death of colorectal cancer cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000367410200097 | - |
dc.identifier.doi | 10.1016/j.colsurfb.2015.08.039 | - |
dc.identifier.bibliographicCitation | COLLOIDS AND SURFACES B-BIOINTERFACES, v.135, pp.793 - 801 | - |
dc.identifier.scopusid | 2-s2.0-84940755142 | - |
dc.citation.endPage | 801 | - |
dc.citation.startPage | 793 | - |
dc.citation.title | COLLOIDS AND SURFACES B-BIOINTERFACES | - |
dc.citation.volume | 135 | - |
dc.contributor.affiliatedAuthor | Sundaramoorthy, Pasupathi | - |
dc.contributor.affiliatedAuthor | Baskaran, Rengarajan | - |
dc.contributor.affiliatedAuthor | Mishra, Siddhartha Kumar | - |
dc.contributor.affiliatedAuthor | Jeong, Keun-Yeong | - |
dc.contributor.affiliatedAuthor | Oh, Seung Hyun | - |
dc.contributor.affiliatedAuthor | Yoo, Bong Kyu | - |
dc.contributor.affiliatedAuthor | Kim, Hwan Mook | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Nanoparticle | - |
dc.subject.keywordAuthor | Self-micellizing anticancer lipid | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | Autophagy | - |
dc.subject.keywordAuthor | Colorectal cancer | - |
dc.subject.keywordPlus | LIPOSOMAL NANOPARTICLES | - |
dc.subject.keywordPlus | ANTITUMOR EFFICACY | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | PLATFORM | - |
dc.subject.keywordPlus | SPHINGOLIPIDS | - |
dc.subject.keywordPlus | IRINOTECAN | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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