A new naphthalene glycoside from Chimaphila umbellata inhibits the RANKL-stimulated osteoclast differentiation
DC Field | Value | Language |
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dc.contributor.author | Shin, Byong-kyu | - |
dc.contributor.author | Kim, Jinhee | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.contributor.author | Piao, Hui-Shan | - |
dc.contributor.author | Park, Jeong Hill | - |
dc.contributor.author | Hwang, Gwi Seo | - |
dc.date.available | 2020-02-28T07:43:40Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2015-11 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/9973 | - |
dc.description.abstract | A new naphthalene glycoside was isolated from the leaves and stems of Chimaphila umbellata Barton. Its chemical structure was elucidated to be 2,7-dimethyl-1,4-dihydroxynaphthalene-1-O-beta-d-glucopyranoside (DMDHNG), based on spectroscopic evidence. DMDHNG significantly inhibited the receptor activator of nuclear factor-kappa B ligand (RANKL)-induced tartrate-resistant acid phosphatase (TRAP) activity and the formation of multinucleated osteoclasts in a dose-dependent manner. In addition, the new glycoside inhibited the RANKL-induced mRNA expression of osteoclast-associated genes that encode TRAP, cathepsin K, and another transcription factor-nuclear factor of activated T-cells c1. We believe that the inhibitory effects of DMDHNG on the osteoclast differentiation may be exploited for a therapeutic benefit. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PHARMACEUTICAL SOC KOREA | - |
dc.relation.isPartOf | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.subject | KAPPA-B | - |
dc.subject | NFATC1 | - |
dc.subject | ACTIVATION | - |
dc.subject | PU.1 | - |
dc.title | A new naphthalene glycoside from Chimaphila umbellata inhibits the RANKL-stimulated osteoclast differentiation | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000364971800017 | - |
dc.identifier.doi | 10.1007/s12272-015-0598-3 | - |
dc.identifier.bibliographicCitation | ARCHIVES OF PHARMACAL RESEARCH, v.38, no.11, pp.2059 - 2065 | - |
dc.identifier.kciid | ART002048279 | - |
dc.identifier.scopusid | 2-s2.0-84947127594 | - |
dc.citation.endPage | 2065 | - |
dc.citation.startPage | 2059 | - |
dc.citation.title | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.citation.volume | 38 | - |
dc.citation.number | 11 | - |
dc.contributor.affiliatedAuthor | Kim, Jinhee | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.contributor.affiliatedAuthor | Hwang, Gwi Seo | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Chimaphila umbellata | - |
dc.subject.keywordAuthor | 2,7-Dimethyl-1,4-dihydroxynaphthalene-1-O-beta-D-glucopyranoside | - |
dc.subject.keywordAuthor | Osteoclast | - |
dc.subject.keywordAuthor | Receptor activator of nuclear factor-kappa B ligand | - |
dc.subject.keywordAuthor | Tartrate-resistant acid phosphatase | - |
dc.subject.keywordPlus | KAPPA-B | - |
dc.subject.keywordPlus | NFATC1 | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PU.1 | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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