https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/360 2026-07-24T12:21:56Z 2026-07-24T12:21:56Z Komatsu, Keiji Kim, Jasper Her, Nicholas Alpers, Ryan Saito, Natsumi Shibata, Rune Fedorowicz, Irina Kim, Sei Jin Kim, Naryung Lu, Tammy Tran, Andrew Lim, Jisub Sakaguchi, Wakako Sato, Takuma Haga, Shugo Matsuura, Takanori Park, Wonhee Ogawa, Takahiro https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/217892 2026-07-03T03:00:26Z 2026-06-01T00:00:00Z

Title: The surface-agnostic advantage for peri-implant health: UV photofunctionalization as a positive-sum strategy for biofilm suppression and soft-tissue barrier-a systematic review with qualitative synthesis Authors: Komatsu, Keiji; Kim, Jasper; Her, Nicholas; Alpers, Ryan; Saito, Natsumi; Shibata, Rune; Fedorowicz, Irina; Kim, Sei Jin; Kim, Naryung; Lu, Tammy; Tran, Andrew; Lim, Jisub; Sakaguchi, Wakako; Sato, Takuma; Haga, Shugo; Matsuura, Takanori; Park, Wonhee; Ogawa, Takahiro Abstract: PurposeLong-term dental implant success depends on a biologic "race to the surface," in which osteogenic cells, peri-implant soft-tissue cells, and bacterial pathogens compete for early dominance at the implant-tissue interface. Because implant surface design is often optimized for one objective at the expense of another (e.g., micro-roughness to accelerate osteoconductivity but with increased plaque-retention risk; relatively smooth transmucosal surfaces to discourage bacterial attachment despite uncertainty regarding optimal soft-tissue integration), strategies that enhance peri-implant health without forcing topographical trade-offs are needed. Ultraviolet (UV) photofunctionalization-by removing storage-acquired hydrocarbons ("biological aging") and converting surfaces to a high-energy, superhydrophilic state-has been proposed as a chairside, topography-preserving approach to improve interfacial biology. This systematic review evaluates whether UV photofunctionalization of titanium and zirconia surfaces provides clinically relevant advantages for (1) reduction of bacterial attachment and biofilm formation, (2) peri-implant soft-tissue responses relevant to mucosal sealing, and (3) human clinical outcomes.MethodsAfter systematic literature search, screening and full-text evaluation, a total of 34 articles, including 9 bacterial/biofilm, 13 soft-tissue (1 overlapping between bacterial and soft-tissue), and 13 clinical studies were selected. Findings were synthesized qualitatively with attention to protocol heterogeneity (UV wavelength band, exposure duration, device configuration, and material and surface types).ResultsAcross experimental models, UV photofunctionalization most consistently reduced early bacterial attachment and/or early biofilm accumulation across several titanium surface topographies, supporting an early anti-adhesive and biofilm-suppressive phenotype. Soft-tissue studies generally demonstrated enhanced fibroblast/epithelial attachment, spreading, and functional behaviors relevant to sealing on both titanium and zirconia, although the optimal underlying topography for soft-tissue integration remains unresolved. Clinically, the most consistent signal was accelerated and enhanced implant stability development, while selected studies also suggested favorable trends in peri-implant soft-tissue parameters and/or crestal bone maintenance. However, clinical outcomes remained variable and were limited by heterogeneity in UV protocols, surface systems, endpoints, and follow-up duration.ConclusionsUV photofunctionalization can be conceptualized as a surface-agnostic physicochemical reactivation technology: a topography-preserving enhancement that restores high surface energy and favorable surface chemistry without altering the underlying surface architecture. Current evidence for this concept is strongest for titanium, whereas supportive evidence for zirconia is emerging primarily from soft-tissue and interface-focused models. This interface-first, positive-sum strategy may allow clinicians to select zone-specific topographies (e.g., smooth transmucosal regions and rough endosteal regions) while maximizing soft-tissue affinity and suppressing early colonization. Although current clinical evidence most strongly supports accelerated osseointegration/stability development, further longitudinal studies with standardized peri-implant health, microbiologic, and mucosal inflammatory endpoints are needed to clarify the long-term translational impact of UV photofunctionalization on peri-implant disease prevention.

2026-06-01T00:00:00Z Cha, Chae-Ryeong Kim, Young-Sung Imazato, Satoshi Kim, Dae-Joon Seol, Yang-Jo Park, Chang-Joo Yeo, In-Sung L. https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/219050 2026-07-10T07:00:17Z 2026-06-01T00:00:00Z

Title: In Vitro and In Vivo Evaluation of Yttria-Niobia-Stabilized Zirconia Sandblasted Surface at Bone-Implant Interface with 3-Dimensional Visualization via Advanced Hard Tissue Clearing Authors: Cha, Chae-Ryeong; Kim, Young-Sung; Imazato, Satoshi; Kim, Dae-Joon; Seol, Yang-Jo; Park, Chang-Joo; Yeo, In-Sung L. Abstract: Titanium is widely acknowledged as the "gold standard" for dental implants because of its superior biocompatibility and osseointegration capabilities. However, it is limited by the possibility of metal allergies, aesthetic concerns such as gray discoloration visible through the thin gingiva, and the risk of corrosion. To overcome these limitations, metal-free implant materials, particularly yttria-niobia-stabilized tetragonal zirconia polycrystals ((Y,Nb)-TZP), have attracted increasing attention. Zirconia has been noted for its advantages, including promising mechanical properties, biocompatibility, aesthetics, and reduced bacterial adhesion. Despite these findings, comparative studies of sandblasted, large-grit, acid-etched (SLA) titanium and (Y,Nb)-TZP are limited. This study aimed to compare the in vitro osteogenic potential and in vivo osseointegration of sandblasted (Y,Nb)-TZP implants with those of conventional SLA titanium implants using 3-dimensional evaluation. (Y,Nb)-TZP implants demonstrated comparable in vitro and in vivo results to SLA titanium, despite significantly lower surface roughness. Early cell attachment and spreading were observed on (Y,Nb)-TZP, whereas alkaline phosphatase activity and late-stage osteogenic gene expression increased over time in both groups without intergroup differences. In in vivo experiments, no significant between-group differences were observed in bone-to-implant contact, bone area, and dynamic bone remodeling indices. Three-dimensional-based analysis revealed similar overall bone remodeling volumes but distinct spatial distributions of newly formed bone around the implant threads, providing additional insights into the subcortical peri-implant bone area. In conclusion, sandblasted (Y,Nb)-TZP implants exhibited osteogenic potential and osseointegration comparable to those of SLA titanium implants, supporting the potential clinical applicability of (Y,Nb)-TZP as an alternative implant material.

2026-06-01T00:00:00Z Park, Won-Bae Sadilina, Sofya Han, Jiyoung Thoma, Daniel Stefan Lim, Hyun-chang https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/210366 2026-01-19T06:30:37Z 2025-12-01T00:00:00Z

Title: Maxillary sinus hypoplasia relevant to dental implant treatment: a narrative review Authors: Park, Won-Bae; Sadilina, Sofya; Han, Jiyoung; Thoma, Daniel Stefan; Lim, Hyun-chang Abstract: This comprehensive narrative review provides an overview of the current scientific evidence regarding maxillary sinus hypoplasia (MSH). This review highlights several variants of MSH that are relevant to implant planning and treatment in daily clinical practice. MSH is characterized by a reduction in sinus volume, which contrasts with maxillary sinus pneumatization, a condition that has received more clinical attention. Nevertheless, certain types of MSH can significantly impact implant surgery and the management of associated complications. The maxillary sinus volume can be affected by factors such as infection, trauma, genetic predispositions, and changes within the sinus or adjacent anatomical structures, including the nasal cavity and the ethmoid sinus. In cases of MSH, the maxillary sinus floor is positioned more cranially than the nasal floor, and the distance between the lamina papyracea of the eye and the middle meatus antrostomy point increases horizontally. Several variants of MSH potentially affect implant therapy. Chronic maxillary sinus atelectasis, which results from persistent ostium blockage, may have clinical implications, particularly when implant-related infections occur in the MS. Inferior meatus pneumatization involves a lateral expansion of the nasal cavity, requiring a nasal floor elevation procedure when placing implants in the posterior maxilla. Additionally, the formation of an ethmomaxillary sinus may create a septum-like structure in the distal area of the maxillary sinus, necessitating two separate bone access windows during the sinus floor elevation procedure. Given these considerations, it is crucial for clinicians to be aware of MSH. Accurate diagnosis of MSH requires the use of 3-dimensional radiography techniques, such as cone-beam computed tomography.

2025-12-01T00:00:00Z Matsuura, Takanori Komatsu, Keiji Suzumura, Toshikatsu Stavrou, Stella Juanatas, Mary Lou Park, Wonhee Ogawa, Takahiro https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/211724 2026-03-30T01:01:43Z 2025-08-01T00:00:00Z

Title: Enhanced functionality and migration of human gingival fibroblasts on vacuum ultraviolet light-treated titanium: An implication for mitigating cellular stress to improve peri-implant cellular reaction Authors: Matsuura, Takanori; Komatsu, Keiji; Suzumura, Toshikatsu; Stavrou, Stella; Juanatas, Mary Lou; Park, Wonhee; Ogawa, Takahiro Abstract: Purpose: The maintenance of peri-implant health relies significantly on the integrity of the peri-implant seal, particularly vulnerable at the interface between implant abutment and soft tissue. Early healing stages around implants involve cellular exposure to oxidative stress. This study aimed to investigate whether vacuum ultraviolet (VUV)-treated titanium augments the growth and functionality of human gingival fibroblasts while mitigating cellular stress. Methods: Machined titanium plates underwent treatment with 172 nm VUV light for one minute, with untreated plates as controls. Human gingival fibroblasts were cultured on treated and untreated plates, and their behavior, growth, and functionality were assessed. Functionally impaired fibroblasts, treated with hydrogen peroxide, were also cultured on these titanium plates, and plate-to-plate transmigration ability was evaluated. Results: Fibroblasts on VUV-treated titanium exhibited a 50% reduction in intracellular reactive oxygen species production compared to controls. Additionally, glutathione, an antioxidant, remained undepleted in cells on VUV-treated titanium. Furthermore, the expression levels of inflammatory cytokines IL-1 beta and IL-8 decreased by 40-60% on VUV-treated titanium. Consequently, fibroblast attachment and proliferation doubled on VUV-treated titanium compared to those in the controls, leading to enhanced cell retention. Plate-to-plate transmigration assays demonstrated that fibroblasts migrated twice as far on VUV-treated surfaces compared to those in the controls. In particular, the transmigration ability, impaired in functionally impaired fibroblasts on the controls, was preserved on VUV-treated titanium. Conclusions: VUV-treated titanium promotes the growth, function, and migration of human gingival fibroblasts by reducing cellular stress and enhancing antioxidative capacity. Notably, the transmigration ability significantly improved on VUV-treated titanium.

2025-08-01T00:00:00Z