https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/462 2026-07-03T23:05:25Z 2026-07-03T23:05:25Z Nahm, Minu Ko, Shin-Woong Yi, Hyeong-Joong Chun, Hyeong-Joon Na, Min-Kyun Lee, Young-Jun Kim, KyuNam Lee, Sang Hyung Ryu, Jaiyoung Song, Simon Han, Kunhee Choi, Kyu-Sun https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/213328 2026-06-17T05:00:17Z 2026-05-01T00:00:00Z

Title: Prediction of Posterior Communicating Artery Aneurysm Rupture Risk: A Multivariate Analysis of Aneurysm and Surrounding Arterial Morphological Factors Authors: Nahm, Minu; Ko, Shin-Woong; Yi, Hyeong-Joong; Chun, Hyeong-Joon; Na, Min-Kyun; Lee, Young-Jun; Kim, KyuNam; Lee, Sang Hyung; Ryu, Jaiyoung; Song, Simon; Han, Kunhee; Choi, Kyu-Sun Abstract: Background/Objectives: Recent studies have increasingly focused on the morphological characteristics of surrounding arteries as rupture predictors, particularly because these vessel configurations remain stable before and after aneurysm rupture, providing a reliable anatomical substrate for risk assessment. This study aimed to identify independent predictors of rupture by evaluating both aneurysmal and internal carotid artery (ICA) morphological characteristics. Methods: We retrospectively analyzed imaging data from 64 patients with posterior communicating artery (PcomA) aneurysms who underwent treatment at a single tertiary center between 2018 and 2022, including 25 ruptured aneurysms (39.1%). Only treated aneurysms were included to ensure the availability of high-quality pre-treatment digital subtraction angiography (DSA) suitable for three-dimensional (3D) reconstruction and centerline-based analysis. Seventeen aneurysm morphological parameters and thirteen ICA-related parameters were measured. Because time-to-event data were not available, logistic regression analysis was performed with rupture status as the outcome variable. Receiver operating characteristic (ROC) curve analyses were conducted to evaluate discriminative performance. Results: Multivariate logistic regression revealed that three ICA-associated factors—the tortuosity of the communicating ICA segment (Tcco), the ICA cross-sectional area at the PcomA origin (Pcs), and the angle between the ICA and PcomA (θ2)—were independently associated with rupture. Among aneurysm-related factors, Maximum 3D Diameter remained significantly related to rupture risk. ROC analyses demonstrated that Maximum 3D Diameter had the highest discriminative value (AUC 0.779; cut-off 7.805 mm), followed by Pcs, Tcco, and θ2. Conclusions: Both aneurysm morphology and the anatomical configuration of surrounding arteries significantly contribute to rupture risk in PcomA aneurysms. Incorporating parent-vessel morphological features into rupture-risk assessment may enhance patient-specific decision-making.

2026-05-01T00:00:00Z Yoo, Seung-Jin Lee, Hyun Myung, Jae Kyung Choi, Yun Young Lee, Soo Jin https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/217703 2026-06-29T05:00:39Z 2026-05-01T00:00:00Z

Title: Rapid Spontaneous Tumor Regression Mimicking Pseudoprogression in Pembrolizumab-treated Non–small Cell Lung Cancer Authors: Yoo, Seung-Jin; Lee, Hyun; Myung, Jae Kyung; Choi, Yun Young; Lee, Soo Jin Abstract: Atypical tumor responses can occur during immune checkpoint inhibitor therapy. A 71-year-old man receiving pembrolizumab treatment for stage IV non–small cell lung cancer was found on 18F-FDG PET/CT to have developed new lesions in the stomach, left adrenal gland, and lungs. Because a gastric biopsy confirmed metastatic disease, treatment was discontinued. Remarkably, all lesions resolved after 4 weeks without any treatment. Pembrolizumab therapy was restarted, and follow-up CT showed further reduction in the lung cancer without new lesions. This case of spontaneous regression of gastric metastasis mimicking a pseudoprogression response to pembrolizumab treatment highlights the possibility of unusual presentations during immunotherapy.

2026-05-01T00:00:00Z Kim, Woo-Joong Lee, Hye-Soon Bang, So-Young Bin Joo, Young Kang, Bo-Kyeong Kim, Mimi Kim, Hyunsung Park, Sung Yul Park, Woong-Yang Shin, Eui-Cheol Bae, Sang-Cheol https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/213857 2026-06-22T01:00:37Z 2026-04-01T00:00:00Z

Title: Treatment nonresponders in lupus nephritis characteristically exhibit persistent type I interferon signalling in monocytes: a longitudinal single-cell transcriptomic analysis Authors: Kim, Woo-Joong; Lee, Hye-Soon; Bang, So-Young; Bin Joo, Young; Kang, Bo-Kyeong; Kim, Mimi; Kim, Hyunsung; Park, Sung Yul; Park, Woong-Yang; Shin, Eui-Cheol; Bae, Sang-Cheol Abstract: Objectives: We aimed to characterise the dynamic transcriptional changes associated with treatment responses in lupus nephritis (LN) through longitudinal single-cell RNA sequencing analysis of peripheral blood mononuclear cells (PBMCs) during standard-of-care induction therapy. Methods: We leveraged the Korean Unlimited multi-Dimensional Omics research in Systemic lupus erythematosus cohort, comprising patients with biopsy-proven active proliferative LN. Single-cell RNA sequencing of PBMCs was conducted at baseline and subsequently at 3, 6, and 12 months following initiation of therapy (n = 10). For validation purposes, bulk RNA sequencing of monocytes was performed in an independent patient group at baseline and at 3 months (n = 13). Renal response was classified as complete response or nonresponse at 12 months according to predefined criteria. Results: In single-cell RNA sequencing analysis of patients with LN, the myeloid cell population—particularly classical and intermediate monocytes—demonstrated the highest number of differentially expressed genes following induction therapy. Weighted gene coexpression network analysis identified distinct gene modules closely associated with treatment responses. Complete responders exhibited progressive suppression of type I interferon (IFN-I) signalling, whereas nonresponders maintained persistent IFN-I-driven gene expression characterised by sustained inflammatory features. Bulk RNA sequencing of monocytes from an independent group of patients with LN confirmed that 6 IFN-I-responsive genes (IRF7, ISG15, LY6E, IFI44, IFI44L, and IFI6) were significantly downregulated by 3 months in complete responders, but not in nonresponders. This gene signature correlated with both proteinuria and disease activity scores. Conclusions: This study demonstrates that persistent IFN-I-driven gene expression in monocytes characterises treatment resistance in LN. Our findings suggest that early transcriptional profiling may enable timely identification of nonresponders and warrant further investigation in larger, independent cohorts.

2026-04-01T00:00:00Z Kim, Hae Young Seo, Nieun Oh, Soon Nam Moon, Sung Kyoung Lee, Chul-min Jang, Jong Keon Kim, Bohyun Cho, Seung Hyun Park, Jun Seok Park, Seong Ho Lim, Joon Seok https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/212336 2026-04-27T00:00:14Z 2026-02-01T00:00:00Z

Title: How best to combine DWI and T2WI to predict pathologic complete response: a multi-center study on interpreting MRI following chemoradiotherapy of rectal cancer Authors: Kim, Hae Young; Seo, Nieun; Oh, Soon Nam; Moon, Sung Kyoung; Lee, Chul-min; Jang, Jong Keon; Kim, Bohyun; Cho, Seung Hyun; Park, Jun Seok; Park, Seong Ho; Lim, Joon Seok Abstract: Objectives To explore the different criteria of integrating diffusion-weighted imaging (DWI) for predicting pathologic complete response (pCR) of rectal cancer on post-chemoradiotherapy (CRT) MRI. Materials and methods In this multi-center retrospective study, five radiologists reviewed pre- and post-CRT MRIs of patients with rectal cancer diagnosed in 2017-2021. In addition to mrTRG, three criteria were assessed: "AND" criterion (mrTRG 1-2 and absence of DWI restriction considered as CR), "OR" criterion (mrTRG 1-2 or absence of restriction), and a modified MR tumor regression grade (modMR-TRG). A crossed random effects model was used to pool sensitivity and specificity across five radiologists. F1 score and positive predictive value (PPV) were analyzed across varying pCR rates. Results In 146 patients (median age [IQR], 63 [57-70] years; 87 men), the AND criterion yielded higher specificity (77.4% [63.3-80.0%] vs 75.3% [60.5-79.0%], p = 0.001) without significant difference in sensitivity (63.9% [42.8-75.3%] vs 67.5% [45.3-76.0%], p = 0.063) compared with mrTRG. OR criterion yielded higher sensitivity (86.1% [65.3-89.3%]; p < 0.001) but lower specificity (49.5% [36.2-62.6%]; p < 0.001). The modMR-TRG demonstrated similar effects to the OR criterion. Assuming a 20% pCR rate, PPV and F1 score of the AND criterion (point estimate of 41.4% and 50.3%, respectively) were higher than those of the OR criterion (PPV, 29.9%; F1 score, 44.4%), although the difference diminished with increasing pCR rate. Conclusion The AND criterion-which utilizes DWI complementarily to further exclude patients with residual tumors after initial screening on T2WI-should be preferred over other criteria giving greater emphasis on DWI.

2026-02-01T00:00:00Z