https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/498 2026-07-24T12:45:19Z 2026-07-24T12:45:19Z Cha, Jong Ho Kang, Eungu Na, Jae Yoon Ryu, Soorack Choi, Young-Jin Kim, Ja Hye https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/219174 2026-07-15T06:00:25Z 2026-07-01T00:00:00Z

Title: Incidence and multisystem preadolescent complications of Turner syndrome: a nationwide study Authors: Cha, Jong Ho; Kang, Eungu; Na, Jae Yoon; Ryu, Soorack; Choi, Young-Jin; Kim, Ja Hye Abstract: Background: Turner syndrome (TS) is the most common sex chromosome aneuploidy and is associated with various comorbidities. Using data from the National Health Screening Program for Infants and Children (NHSPIC), we aimed to investigate the multisystem comorbidities and growth trajectories of patients with TS in South Korea. Methods: A total of 1,647,140 female individuals born between 2007 and 2017 registered in the National Health Insurance Service were included in this study. Diagnoses of TS were based on the World Health Organization's International Classification of Diseases, Tenth Revision (ICD-10). Multisystem comorbidities were categorized into cardiovascular, endocrine, neurologic, and neurosensory disorders. The risk of comorbidities was investigated using a Cox proportional-hazards regression analysis. Each individual was observed until 2020.12.31. Growth measurements from 0 to 6 years were obtained from the NHSPIC and converted into Z-scores. Growth curves of children with TS from birth to age 6 were plotted using a locally estimated scatterplot smoothing function. Results: Overall, 514 girls were diagnosed with TS. The incidence of TS was 1 per 3203 female live births over the observation period, with a median age at diagnosis of 7.6 years. Compared to the control group, the TS group had an elevated risk of various complications: congenital heart disease (CHD) (adjusted hazard ratio [aHR] 3.51; 95 % confidence interval [CI] 2.79-4.42), short stature (aHR 23.19; 95 % CI 20.99-25.61), and developmental delay (aHR 6.21; 95 % CI 4.65-8.29). Growth curves for girls with TS revealed growth impairments evident from birth. Conclusion: Our nationwide study emphasizes the importance of early diagnosis by highlighting the risk of various early TS complications. Clinicians should recognize that TS may present with early growth deficiency and a broad spectrum of multisystem comorbidities, underscoring the importance of timely diagnosis and multidisciplinary management.

2026-07-01T00:00:00Z Kim, Ji Hong Kim, Yunjin Oraha, Kathy Michelle Park, Hae Min Kim, Yu Jeong Lim, Han Woong Sung, Yoon-Kyoung Welsbie, Derek S. Lee, Won June https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/213191 2026-06-10T01:00:16Z 2026-06-01T00:00:00Z

Title: Incidence of glaucoma in patients with systemic lupus erythematosus: a nationwide cohort study in South Korea Authors: Kim, Ji Hong; Kim, Yunjin; Oraha, Kathy Michelle; Park, Hae Min; Kim, Yu Jeong; Lim, Han Woong; Sung, Yoon-Kyoung; Welsbie, Derek S.; Lee, Won June Abstract: Background/aims To assess the incidence of glaucoma in patients with systemic lupus erythematosus (SLE) and to identify associated risk factors using a nationwide population-based cohort. Methods This retrospective cohort study analysed data from the Korean National Health Insurance Service (2008-2022). A total of 9682 patients with SLE were identified using ICD-10 code M32 and rare intractable disease code V136 and matched 1:1 to non-SLE controls by age and sex. The incidence of glaucoma (ICD-10 codes H40 and H42) and glaucoma suspect (H40.0) was assessed. Multivariate logistic regression was used to identify risk factors for glaucoma, including long-term corticosteroid use (>= 180 days). Results The incidence of glaucoma was significantly higher in the SLE group than in controls (11.34% vs 3.74%; p<0.0001), with a greater prevalence in younger patients (<40 years) and females. Glaucoma suspect cases were also more common in the SLE group (35.56% vs 30.25%; p<0.0001). SLE was independently associated with glaucoma (adjusted OR: 2.00, 95% CI 1.69 to 2.38), and prolonged corticosteroid use further increased the risk (OR: 1.75, 95% CI 1.51 to 2.02). Annual incidence trends showed a rising pattern over time, especially among SLE patients. Conclusions SLE is associated with an increased risk of glaucoma, particularly among younger individuals and females. Prolonged corticosteroid therapy significantly contributes to this risk. These findings support the need for regular ophthalmic screening and judicious corticosteroid management in patients with SLE.

2026-06-01T00:00:00Z Ro, Sun Kyun Kim, Jiyeong Ryu, Soorack Kim, Joon Bum https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/213879 2026-06-22T01:30:26Z 2026-05-01T00:00:00Z

Title: Mechanical versus bioprosthetic heart valves in patients on hemodialysis Authors: Ro, Sun Kyun; Kim, Jiyeong; Ryu, Soorack; Kim, Joon Bum Abstract: Objectives: Appropriate valve selection in patients on hemodialysis requiring valve replacement is a highly contentious issue because of these patients’ short life expectancy and accelerated deterioration of bioprosthetic valves. This study aims to analyze clinical outcomes on the basis of the types of prosthetic valves and to estimate life expectancy and valve durability in this cohort. Methods: In total, 765 patients on hemodialysis undergoing first-time valve replacement were extracted from the Korean National Health Insurance Sharing Service database. Clinical outcomes were compared between the bioprosthetic (n = 421) and mechanical (MP; n = 344) valve groups. An age-dependent subgroup analysis was conducted, and the median survival time was calculated. A competing risk analysis for late clinical events was also performed. Results: After adjustment, the early clinical outcomes and late mortality were comparable between the 2 groups. Redo aortic valve replacements (AVRs) occurred more frequently in the bioprosthetic group (1.3%/patient-year vs 0.3%/patient-year; P = .002), whereas gastrointestinal bleeding was more common in the MP group (7.0%/patient-year vs 4.8%/patient-year; P = .010). The 2 groups did not show significant survival differences in all age-dependent subgroups. The estimated median survival times were 6.6, 4.0, and 2.1 years for patients aged <50, 50-64, and ≥65 years, respectively. Competing risk analysis showed a lower prevalence of redo AVRs and a greater prevalence of major bleeding events with MP use (adjusted subdistribution hazard ratio, 0.24 [0.09-0.66]; P = .006 and 1.46 [1.13-1.89]; P = .004). Conclusions: Given the considerably short lifespan of patients on hemodialysis, bioprosthetic valves may be a reasonable option for younger patients, except for those with hypercalcemia or potential candidates for kidney transplantation.

2026-05-01T00:00:00Z Kim, Daeho Ryu, Soorack Min, Ji Young Lee, Hyunji Kim, Eunkyung https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/217620 2026-06-26T03:00:20Z 2026-05-01T00:00:00Z

Title: Randomized Clinical Trial of Imagery Stabilization and Rescripting Therapy for Psychiatric Outpatients with Posttraumatic Stress Disorder Authors: Kim, Daeho; Ryu, Soorack; Min, Ji Young; Lee, Hyunji; Kim, Eunkyung Abstract: Purpose: To examine the safety and effectiveness of a novel psychotherapy based on imagery techniques, we conducted a randomized clinical trial comparing imagery stabilization and rescripting therapy (ISRT) with non-trauma-focused cognitive behavioral therapy (CBT) for adults with posttraumatic stress disorder (PTSD). Materials and Methods: Eight sessions of 60-minute ISRT were conducted for the treatment condition (n=59), while the control group received eight sessions of 60 minutes of CBT (n=27). The Clinician-Administered PTSD Scale for Diagnostic and Statistical tered by clinicians, while self-questionnaires were administered at pretreatment, posttreatment, and the 6-month follow-up. Results: Forty-two participants in the ISRT group and 20 participants in the CBT group completed more than six sessions; thus, dropout rates were not significantly different between the groups (17/59, 28.8% vs. 7/27, 25.9%, respectively). Although no statistical differences were found between conditions, both completer and intention-to-treatment analyses revealed that clinical status, PTSD symptoms, and quality of life favored ISRT after treatment and 6 months later. Conclusion: Our findings suggest that ISRT is a safe and effective treatment option for PTSD.

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