ScholarWorks Community: https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/71 2026-07-19T14:12:03Z 2026-07-19T14:12:03Z Effects of oxycodone on tonic levels and phasic release of serotonin in the rat nucleus accumbens core Kwak, Youngjong Rojas Cabrera, Juan M. Vettleson-Trutza, Sara A. Scheitler, Kristen M. Karanovic, Una Oesterle, Tyler S. Blaha, Charles D. Oh, Yoonbae Shin, Hojin Jang, Dong Pyo Lee, Kendall H. https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/212523 2026-05-09T05:01:25Z 2026-10-01T00:00:00Z Title: Effects of oxycodone on tonic levels and phasic release of serotonin in the rat nucleus accumbens core Authors: Kwak, Youngjong; Rojas Cabrera, Juan M.; Vettleson-Trutza, Sara A.; Scheitler, Kristen M.; Karanovic, Una; Oesterle, Tyler S.; Blaha, Charles D.; Oh, Yoonbae; Shin, Hojin; Jang, Dong Pyo; Lee, Kendall H. Abstract: Despite widespread oxycodone misuse, the role of serotonin in opioid addiction remains understudied compared to dopamine. This study investigated the acute effects of oxycodone (2.5 mg/kg, i.v.) on serotonergic neurotransmission in the rat nucleus accumbens core using high-resolution electrochemical methods. We employed fast-scan cyclic voltammetry (FSCV) to monitor medial forebrain bundle stimulation-evoked phasic release and N-shaped multiple cyclic square wave voltammetry (N-MCSWV) to measure tonic concentrations in urethane-anesthetized rats. Results demonstrated a distinct dissociation between tonic and phasic dynamics. Tonic serotonin levels increased significantly (+23.4 nM) from baseline 1-h post-administration. Conversely, stimulation-evoked phasic release initially increased (+24%) but subsequently declined below baseline. Kinetic analysis revealed that serotonin production and maximum reuptake rates followed a similar pattern of initial increase followed by a decrease. In conclusion, oxycodone acutely modulates serotonergic signaling in the nucleus accumbens core by differentially affecting phasic and tonic neurotransmission. These findings demonstrate oxycodone induces temporal dynamics in phasic versus tonic serotonergic signaling in the nucleus accumbens core, highlighting the value of multimodal electrochemical approaches for dissecting opioid neurochemical effects. 2026-10-01T00:00:00Z From Bioelectronic Interfaces to AI: Scalable Spatiotemporal Physiological Sensing Platforms 백상훈 https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/219025 2026-07-16T22:33:20Z 2026-06-25T00:00:00Z Title: From Bioelectronic Interfaces to AI: Scalable Spatiotemporal Physiological Sensing Platforms Authors: 백상훈 2026-06-25T00:00:00Z Skin-Integrated Optoelectronic Platforms for Scalable Spatiotemporal Physiological Sensing 백상훈 https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/219024 2026-07-16T22:33:18Z 2026-05-14T00:00:00Z Title: Skin-Integrated Optoelectronic Platforms for Scalable Spatiotemporal Physiological Sensing Authors: 백상훈 2026-05-14T00:00:00Z Multimodal, Spatiotemporal Physiological Sensing with Flexible Active-Matrix Platforms : Toward AI-Driven Monitoring 백상훈 https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/219023 2026-07-16T22:33:17Z 2026-05-07T00:00:00Z Title: Multimodal, Spatiotemporal Physiological Sensing with Flexible Active-Matrix Platforms : Toward AI-Driven Monitoring Authors: 백상훈 2026-05-07T00:00:00Z