https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/324 2026-07-04T07:16:45Z https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/213821 Title: Changes in alcohol consumption and their association with lipid profiles among Korean adults aged 40-69 years: the Korea Genome and Epidemiology Study Authors: Park, Sohyun; Park, Boyoung Abstract: Background and aim: Alcohol consumption influences lipid profiles and cardiovascular risk; however, the longitudinal effects of changes in drinking behavior on serum lipid levels remain unclear. This study evaluated associations between alcohol initiation and cessation and changes in lipid profiles among Korean adults. Methods and results: We analyzed data from the community-based Korean Genome and Epidemiology Study (KoGES), including adults aged 40-69 years. Changes in low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides, and total cholesterol were assessed across follow-up visits. Associations between changes in alcohol intake—initiation, cessation, and average number of standard drinks per day—and lipid changes were estimated using generalized estimating equations adjusted for demographic, lifestyle, and clinical factors. Compared with individuals who remained non-consumers, alcohol initiation was associated with increased HDL-C levels (β = 1.07; 95% CI, 0.60 to 1.55; p < 0.001), with no significant change in LDL-C. Compared with continued consumers, alcohol cessation was associated with decreased HDL-C (β = −2.37; 95% CI, −3.80 to −1.94; p < 0.001), triglycerides (β = −2.92; 95% CI, −5.81 to −0.02; p = 0.049), and total cholesterol (β = −2.30; 95% CI, −3.80 to −0.79; p = 0.003). Each one-standard drink/day increase was associated with higher HDL-C (β = 0.94; 95% CI, 0.51 to 1.36; p < 0.001) and lower LDL-C (β = −0.87; 95% CI, −1.68 to −0.05; p = 0.037). Conclusions: Alcohol initiation and cessation were associated with distinct lipid changes, highlighting metabolic implications of drinking patterns and supporting moderation in alcohol consumption. 2026-07-01T00:00:00Z https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/210928 Title: Assessing the safety of herbal medicine use among type 2 diabetes mellitus patients: A systematic review and meta-analysis Authors: Boulares, Emna; Bragazzi, Nicola Luigi; Yin, Tan Sabrina Chen; Choi, Soo Jeung; Park, Jung Hwan; Han, Dongwoon Abstract: Background Herbal medicines (HM) use among type 2 diabetes mellitus (T2DM) patients has grown tremendously despite the existence of conventional treatments. However, evidence on their safety, potential side effects, and interactions remains scarce. This systematic review and meta-analysis aim to determine the global prevalence of HM use among T2DM patients and assess the safety and potential interactions. Methods A systematic search of four electronic databases was conducted until March 2024. Data were extracted and then assessed through an adapted quality appraisal tool. A meta-analysis estimated the pooled prevalence of HM use among T2DM patients and examined predictors of use. Identified herbs were classified based on safety and potential interactions with pharmacological treatments. The study followed PRISMA guidelines. Results Twenty-two cross-sectional studies from 19 countries were included. The global prevalence of HM use among T2DM patients was 53%, with significant regional variations. The highest prevalence of HM use among T2DM patients is in the African region, accounting for 39.8% of global HM use. Among 49 identified herbs, Opuntia ficus-indica L., Trigonella foenum graecum L. , Allium sativum L. , and Cinnamomum verum J . were the most commonly used. The safety classification reported 7 contraindicated herbs and 19 requiring caution, and 23 considered safe for use. Additionally, 12 herbs reported potential pharmacological interactions. Conclusions Although the use of HM is widespread globally, multiple herbs pose safety concerns. Therefore, to preserve patients’ safety, it is essential to avoid using contraindicated herbs and to seek healthcare practitioner supervision. 2026-05-01T00:00:00Z https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/212876 Title: Comparison of the Prevalence of Obesity and Overweight Among Adults With HIV and the Adult General Population in Korea Authors: Jang, Yoonyoung; Kim, Taehwa; Seong, Hye; Song, Joon Young; Kim, Jung Ho; Choi, Jun Yong; Kim, Shin-Woo; Kim, Youn Jeong; Kim, Sang Il; Nguyen, Thi Huyen Trang; Park, Boyoung Abstract: Background: This study compared the prevalence of overweight and obesity in people living with human immunodeficiency virus (PLWH) with the general population and the trend of overweight/obesity in PLWH and the general population from 2009 to 2020. Methods: A total of 10,980 PLWH aged >= 20 years with national health examination records and 76,783 adults in the general adult population of the Korea National Health and Nutrition Examination Survey were included. The overall and yearly obesity and overweight prevalence rates and standardized prevalence ratios are described. Results: The prevalence of obesity and overweight in PLWH during 2009-2020 was 27.9% (95% confidence interval [CI], 27.0-28.7%) and 23.1% (95% CI, 22.3-23.9%), while those in the general population were 33.7% (95% CI, 33.7-33.7%) and 22.8% (95% CI, 22.8-22.8%), with identical bounds reflecting the high precision facilitated by the large sample size. During 2009-2020, the standardized prevalence ratio of obesity and overweight in the PLWH compared with that in the general population was 0.70 (95% CI, 0.68-0.73) and 0.92 (95% CI, 0.89-0.96). The annual percent change in obesity prevalence was 3.0% annually (P < 0.001) in PLWH and 1.4% (P < 0.001) annually in the general population between 2009 and 2020. Owing to the rapid increase, the prevalence of obesity was higher in PLWH than in the general population in 2019 and 2020. In contrast, the prevalence of overweight did not show a clear increasing or decreasing trend in either group between 2009 and 2020. Conclusion: The prevalence of obesity and overweight in PLWH was lower than that in the general population. However, the rate of increase in obesity prevalence was faster in PLWH than that in the general population. As obesity is associated with the onset of chronic diseases, pathological conditions, and various forms of cancer, more detailed obesity management for PLWH is warranted. 2026-05-01T00:00:00Z https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/212491 Title: Association Between Changes in Socioeconomic Status Before and After Human Immunodeficiency Virus Infection Diagnosis and Mortality Rates in Korea Authors: Jang, Yoonyoung; Kim, Taehwa; Seong, Hye; Kim, Jung Ho; Kim, Shin-Woo; Kim, Youn Jeong; Nguyen, Thi Huyen Trang; Park, Boyoung Abstract: BACKGROUND: This study investigated changes in medical insurance status as a surrogate marker of socioeconomic status after human immunodeficiency virus (HIV) infection, and their association with mortality among people living with HIV in Korea. METHODS: This study included 13,112 individuals newly diagnosed with HIV between 2004 and 2018, identified from the claims data of the National Health Insurance System-National Health Information Database. Participants' medical insurance status was categorized into National Health Insurance (NHI) and medical aid (MA). Using the Cox proportional hazards model, the association between mortality and changes in medical insurance status before and after HIV infection diagnosis was assessed using hazard ratios (HRs) and confidence intervals (CIs). RESULTS: The insurance coverage rates before HIV diagnosis were 95.1% and 4.9% for NHI and MA recipients, respectively. After diagnosis, the insurance coverage rates were 13.4% and 86.6% for MA and NHI recipients, respectively, demonstrating a threefold increase in the proportion of MA recipients. The conversion rate from NHI to MA was highest in the 35-44 and 45-54-year age groups at HIV infection diagnosis (32.9% and 29.4%, respectively). Compared with NHI recipients, the HR was significantly higher among individuals that transitioned from NHI to MA (HR, 1.66; 95% CI, 1.39-1.97) and individuals that remained on MA (HR, 1.74; 95% CI, 1.40-2.18), suggesting a higher mortality rate in these groups. CONCLUSION: In Korea, where highly active antiretroviral therapy is essentially free of charge, a significant association was observed between a decline in medical insurance status following HIV diagnosis and increased mortality.; 연구목적: 본 연구는 인간면역결핍바이러스(HIV) 감염 후 사회경제적 지위의 대체 지표로서 건강보험 자격 변화를 조사하고, 이러한 변화가 HIV 감염인(PLWH)의 사망률과 어떤 관련이 있는지를 분석하였다. 결과: HIV 진단 전후의 보험 자격 변화와 사망률 간의 연관성을 Cox 비례위험모형(Cox proportional hazards model)을 사용하여 추정하였다. PLWH에서 HIV 감염 진단 전 보험 자격은 건강보험(NHI) 95.1%, 의료급여(MA) 4.9%이었으나, HIV 감염 진단 후에는 의료급여 수급 자 비율이 13.4%로 증가하여 의료급여 수급 자 비율이 약 3배 증가하였다. 건강보험에서 의료급여로 전환된 비율은35–44세(32.9%), 45–54세(29.4%) 그룹에서 가장 높게 나타났다. 특히, 건강보험 수급자에 비해, 건강보험에서 의료급여로 전환된 그룹은 사망률이 유의하게 높았으며 (HR: 1.66, 95% CI: 1.39–1.97), 지속적으로 의료급여를 수급한 그룹도 사망률이 건강보험 수급자에 비해 높았다 (HR: 1.74, 95% CI: 1.40–2.18). 결론: 한국에서는 고활성 항레트로바이러스 치료(HAART)가 사실상 무료로 제공됨에도 불구하고, HIV 진단 이후 건강보험 자격의 하락과 사망률 증가 간에 유의한 연관성이 관찰되었다. 2026-04-01T00:00:00Z