https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/353 2026-07-03T21:05:39Z https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/217856 Title: 소아 특발성 편평족에서 종골 절골술시 단일 핀 및 이중핀 고정술 비교 연구 Authors: 배근형 2026-06-05T00:00:00Z https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/214866 Title: Short-term Follow-up Results of Hip Arthroplasty Using a 22mm Ceramic Head Authors: 김이석 2026-05-15T00:00:00Z https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/212897 Title: Osteoclast-derived DEL1 promotes pathological bone formation in ankylosing spondylitis by regulating RUNX2 expression in osteoblasts Authors: Lee, Seung Hoon; Jeon, Chanhyeok; Kim, Dongju; Jo, Hye-Ryeong; Ko, Eunae; Youn, Jeehee; Lee, Seunghun; Choi, Sung Hoon; Park, Ye-Soo; Jo, Sungsin; Kim, Tae-Hwan Abstract: Background: Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by ectopic bone formation. We investigated in vitro and in vivo the role of developmental endothelial locus-1 (DEL1) on new bone formation and determined the association between DEL1 and spinal progression in AS. Methods: DEL1 levels were measured in plasma and facet joint tissues from patients with AS, and in osteoclast-derived medium. Human osteoblast precursor cells were treated with recombinant DEL1 protein and cilengitide trifluoroacetate, an alpha v beta 3 integrin inhibitor, to evaluate their effects on osteoblast differentiation markers. A curdlan-injected SKG mouse model was used to mimic AS pathogenesis. Three weeks after curdlan injection, recombinant DEL1 protein or cilengitide was administered, and the mice's ankle thickness was assessed. The mice were sacrificed after six weeks, and micro-CT and histological analyses were performed. Results: DEL1 expression significantly increased during osteoclast differentiation, peaked at the terminal stage, and correlated with disease progression in AS mice. Systemic plasma DEL1 levels were not different between patients with AS and the control group, but were positively correlated with structural damage (mSASSS; R = 0.3433, p = 0.0195). DEL1 pro-osteogenic effects were neutralized by cilengitide, which attenuated DEL1-induced RUNX2 expression and matrix mineralization. Conclusion: Our findings establish DEL1 as a key osteoclast-derived coupling factor that drives new bone formation in AS. DEL1 promotes pathological bone formation and osteoblast differentiation by signaling through the integrin alpha V beta 3-RUNX2 axis; targeting this pathway may offer a novel approach to prevent structural damage in patients with AS. 2026-05-01T00:00:00Z https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/212943 Title: Long-term effects of preterm birth on cortical folding trajectories in early childhood Authors: Jang, Yong Hun; Kim, Jong Min; Lee, Bong Gun; Hoh, Jeong-Kyu; Lee, Gang Yi; Kim, Hyun Ho; Lyu, Ilwoo; Lee, Hyun Ju Abstract: Cortical folding emerges in the late prenatal period and undergoes rapid reorganization during early childhood. However, the long-term impact of folding alterations associated with preterm birth remains unclear. Herein, we analysed the structural MRI data of 56 preterm children and 206 full-term peers aged 1–7 years. We derived cortical metrics from the reconstructed cortical surfaces using a vertex-wise computation framework to characterize regional folding patterns. We then conducted a combined analysis of the local gyrification index and sulcal depth to explain folding patterns in the preterm brain. Compared with their full-term peers, preterm children exhibited a region-specific impairment pattern characterized by a significantly reduced local gyrification index and sulcal depth in the bilateral superior temporal gyrus and left superior frontal gyrus (P < 0.05). Notably, the sulcal depth in the superior temporal cortex showed significant differences between preterm and full-term children in its association with neurodevelopmental outcomes (P < 0.05), indicating an atypical structure–function relationship in preterm children. The local gyrification index was significantly reduced in the right isthmus cingulate and posterior cingulate gyri (P < 0.05), reflecting a simplified gyral configuration. The study findings suggest several folding patterns that capture diverse mechanisms of morphogenetic disruption, indicating that preterm birth induces persistent region-specific impairments in cortical folding that may affect neurodevelopmental domains. These folding-sensitive markers provide critical insights into the development of targeted interventions to optimize long-term neurodevelopmental outcomes. 2026-05-01T00:00:00Z