https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/354 2026-07-03T21:06:07Z https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/212897 Title: Osteoclast-derived DEL1 promotes pathological bone formation in ankylosing spondylitis by regulating RUNX2 expression in osteoblasts Authors: Lee, Seung Hoon; Jeon, Chanhyeok; Kim, Dongju; Jo, Hye-Ryeong; Ko, Eunae; Youn, Jeehee; Lee, Seunghun; Choi, Sung Hoon; Park, Ye-Soo; Jo, Sungsin; Kim, Tae-Hwan Abstract: Background: Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by ectopic bone formation. We investigated in vitro and in vivo the role of developmental endothelial locus-1 (DEL1) on new bone formation and determined the association between DEL1 and spinal progression in AS. Methods: DEL1 levels were measured in plasma and facet joint tissues from patients with AS, and in osteoclast-derived medium. Human osteoblast precursor cells were treated with recombinant DEL1 protein and cilengitide trifluoroacetate, an alpha v beta 3 integrin inhibitor, to evaluate their effects on osteoblast differentiation markers. A curdlan-injected SKG mouse model was used to mimic AS pathogenesis. Three weeks after curdlan injection, recombinant DEL1 protein or cilengitide was administered, and the mice's ankle thickness was assessed. The mice were sacrificed after six weeks, and micro-CT and histological analyses were performed. Results: DEL1 expression significantly increased during osteoclast differentiation, peaked at the terminal stage, and correlated with disease progression in AS mice. Systemic plasma DEL1 levels were not different between patients with AS and the control group, but were positively correlated with structural damage (mSASSS; R = 0.3433, p = 0.0195). DEL1 pro-osteogenic effects were neutralized by cilengitide, which attenuated DEL1-induced RUNX2 expression and matrix mineralization. Conclusion: Our findings establish DEL1 as a key osteoclast-derived coupling factor that drives new bone formation in AS. DEL1 promotes pathological bone formation and osteoblast differentiation by signaling through the integrin alpha V beta 3-RUNX2 axis; targeting this pathway may offer a novel approach to prevent structural damage in patients with AS. 2026-05-01T00:00:00Z https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/212943 Title: Long-term effects of preterm birth on cortical folding trajectories in early childhood Authors: Jang, Yong Hun; Kim, Jong Min; Lee, Bong Gun; Hoh, Jeong-Kyu; Lee, Gang Yi; Kim, Hyun Ho; Lyu, Ilwoo; Lee, Hyun Ju Abstract: Cortical folding emerges in the late prenatal period and undergoes rapid reorganization during early childhood. However, the long-term impact of folding alterations associated with preterm birth remains unclear. Herein, we analysed the structural MRI data of 56 preterm children and 206 full-term peers aged 1–7 years. We derived cortical metrics from the reconstructed cortical surfaces using a vertex-wise computation framework to characterize regional folding patterns. We then conducted a combined analysis of the local gyrification index and sulcal depth to explain folding patterns in the preterm brain. Compared with their full-term peers, preterm children exhibited a region-specific impairment pattern characterized by a significantly reduced local gyrification index and sulcal depth in the bilateral superior temporal gyrus and left superior frontal gyrus (P < 0.05). Notably, the sulcal depth in the superior temporal cortex showed significant differences between preterm and full-term children in its association with neurodevelopmental outcomes (P < 0.05), indicating an atypical structure–function relationship in preterm children. The local gyrification index was significantly reduced in the right isthmus cingulate and posterior cingulate gyri (P < 0.05), reflecting a simplified gyral configuration. The study findings suggest several folding patterns that capture diverse mechanisms of morphogenetic disruption, indicating that preterm birth induces persistent region-specific impairments in cortical folding that may affect neurodevelopmental domains. These folding-sensitive markers provide critical insights into the development of targeted interventions to optimize long-term neurodevelopmental outcomes. 2026-05-01T00:00:00Z https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/213301 Title: Neglected acromioclavicular joint injury in coracoid process fractures: a retrospective cohort study Authors: Lee, Myung-Sub; Lee, Chang-Hun; Jo, Young-Hoon; Cho, Won-Tae; Seo, Young Wook; Choi, Wan-Sun Abstract: INTRODUCTION: Coracoid process fractures are frequently associated with injuries to the superior suspensory shoulder complex, including the acromioclavicular (AC) joint. However, concomitant AC joint injuries may be overlooked in the acute phase, potentially limiting treatment options. This study aimed to investigate the association between coracoid process fractures and SSSC injuries and to identify imaging-based predictors of concomitant AC joint injury. METHODS: A retrospective single-center cohort study including 60 patients with coracoid process fractures was conducted between February 2016 and April 2023. Coracoid fractures were classified based on anatomical location, and associated SSSC injuries were categorized according to the involved structures. These injuries were evaluated using 3D shoulder CT. Morphological deformity of the SSSC was assessed by measuring the glenoclavicular distance (GCD)-a longitudinal parameter-on final follow-up clavicle AP radiographs. In base fractures, the medial displacement gap was measured on sagittal CT. Statistical analyses included logistic regression and ROC curve analysis to identify predictors of AC joint injury. RESULTS: Among the 60 patients, fractures were located anteriorly in 27 cases, in the middle region in 5 cases, and at the base in 28 cases. AC joint injury was identified in 15 patients, all of whom had base-type fractures. Logistic regression analysis revealed a significant association between base fractures and SSSC injuries (OR = 21.0, p < 0.001). The GCD was significantly different between affected and contralateral sides in base fracture cases (Kruskal-Wallis test, p < 0.001). Receiver operating characteristic (ROC) curve analysis indicated that a displacement gap of ≥ 5.82 mm was predictive of concurrent AC joint injury (AUC = 0.741). CONCLUSIONS: Coracoid process base fractures are significantly associated with injuries to other components of the SSSC. In particular, a displacement gap of 5.82 mm or more suggests a higher likelihood of previously unrecognized AC joint injury. LEVEL OF EVIDENCE: III, retrospective cohort study 2026-05-01T00:00:00Z https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/214926 Title: Bisphosphonate use is associated with reduced fracture rates in a cohort of patients with Parkinson’s disease Authors: Jang, Min Uk; Kim, Min Seong; Hwang, Jihyun; Kim, Hyung Seok; Jo, Sang Won; Kim, Sung Jae Abstract: Purpose: Patients with Parkinson’s disease, often accompanied by osteoporosis, have a higher risk of osteoporotic fractures. However, a large cohort study assessing the preventive effect of bisphosphonates for osteoporotic fracture on patients with Parkinson’s disease is scarce. Methods: This retrospective cohort study included nearly whole population of South Korea during 2002 to 2018 from the national patient database of Korea National Health Insurance Service. Of 608,202 patients with Parkinson’s disease, a total of 7335 patients were selected for index regression model and 5806 patients were further selected for landmark model of 1 year after diagnosis of osteoporosis. Occurrence of osteoporotic fracture was set defined as outcome variable for both regression models. Results: Regression analysis with a landmark model one year after the index diagnosis of osteoporosis showed that the use of bisphosphonates had a significant preventive effect on osteoporotic fractures (hazard ratio [HR] 0.83, 95% confidence interval [CI] 0.73–0.96, p = 0.012). In index regression model, higher age, larger waist circumference, smoking, and history of lymphoma were significant risk factors of osteoporotic fractures. Higher weight and higher physical activity score were significant preventative factors. Conclusion: In the regression analysis with landmark model with 5806 patients, higher age, heavy alcohol consumption, smoking, and history of solid tumor were significant risk factors of osteoporotic fractures. Higher weight was a significant preventative factor. 2026-04-01T00:00:00Z