https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/359 2026-07-24T13:44:12Z https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/217892 Title: The surface-agnostic advantage for peri-implant health: UV photofunctionalization as a positive-sum strategy for biofilm suppression and soft-tissue barrier-a systematic review with qualitative synthesis Authors: Komatsu, Keiji; Kim, Jasper; Her, Nicholas; Alpers, Ryan; Saito, Natsumi; Shibata, Rune; Fedorowicz, Irina; Kim, Sei Jin; Kim, Naryung; Lu, Tammy; Tran, Andrew; Lim, Jisub; Sakaguchi, Wakako; Sato, Takuma; Haga, Shugo; Matsuura, Takanori; Park, Wonhee; Ogawa, Takahiro Abstract: PurposeLong-term dental implant success depends on a biologic "race to the surface," in which osteogenic cells, peri-implant soft-tissue cells, and bacterial pathogens compete for early dominance at the implant-tissue interface. Because implant surface design is often optimized for one objective at the expense of another (e.g., micro-roughness to accelerate osteoconductivity but with increased plaque-retention risk; relatively smooth transmucosal surfaces to discourage bacterial attachment despite uncertainty regarding optimal soft-tissue integration), strategies that enhance peri-implant health without forcing topographical trade-offs are needed. Ultraviolet (UV) photofunctionalization-by removing storage-acquired hydrocarbons ("biological aging") and converting surfaces to a high-energy, superhydrophilic state-has been proposed as a chairside, topography-preserving approach to improve interfacial biology. This systematic review evaluates whether UV photofunctionalization of titanium and zirconia surfaces provides clinically relevant advantages for (1) reduction of bacterial attachment and biofilm formation, (2) peri-implant soft-tissue responses relevant to mucosal sealing, and (3) human clinical outcomes.MethodsAfter systematic literature search, screening and full-text evaluation, a total of 34 articles, including 9 bacterial/biofilm, 13 soft-tissue (1 overlapping between bacterial and soft-tissue), and 13 clinical studies were selected. Findings were synthesized qualitatively with attention to protocol heterogeneity (UV wavelength band, exposure duration, device configuration, and material and surface types).ResultsAcross experimental models, UV photofunctionalization most consistently reduced early bacterial attachment and/or early biofilm accumulation across several titanium surface topographies, supporting an early anti-adhesive and biofilm-suppressive phenotype. Soft-tissue studies generally demonstrated enhanced fibroblast/epithelial attachment, spreading, and functional behaviors relevant to sealing on both titanium and zirconia, although the optimal underlying topography for soft-tissue integration remains unresolved. Clinically, the most consistent signal was accelerated and enhanced implant stability development, while selected studies also suggested favorable trends in peri-implant soft-tissue parameters and/or crestal bone maintenance. However, clinical outcomes remained variable and were limited by heterogeneity in UV protocols, surface systems, endpoints, and follow-up duration.ConclusionsUV photofunctionalization can be conceptualized as a surface-agnostic physicochemical reactivation technology: a topography-preserving enhancement that restores high surface energy and favorable surface chemistry without altering the underlying surface architecture. Current evidence for this concept is strongest for titanium, whereas supportive evidence for zirconia is emerging primarily from soft-tissue and interface-focused models. This interface-first, positive-sum strategy may allow clinicians to select zone-specific topographies (e.g., smooth transmucosal regions and rough endosteal regions) while maximizing soft-tissue affinity and suppressing early colonization. Although current clinical evidence most strongly supports accelerated osseointegration/stability development, further longitudinal studies with standardized peri-implant health, microbiologic, and mucosal inflammatory endpoints are needed to clarify the long-term translational impact of UV photofunctionalization on peri-implant disease prevention. 2026-06-01T00:00:00Z https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/219050 Title: In Vitro and In Vivo Evaluation of Yttria-Niobia-Stabilized Zirconia Sandblasted Surface at Bone-Implant Interface with 3-Dimensional Visualization via Advanced Hard Tissue Clearing Authors: Cha, Chae-Ryeong; Kim, Young-Sung; Imazato, Satoshi; Kim, Dae-Joon; Seol, Yang-Jo; Park, Chang-Joo; Yeo, In-Sung L. Abstract: Titanium is widely acknowledged as the "gold standard" for dental implants because of its superior biocompatibility and osseointegration capabilities. However, it is limited by the possibility of metal allergies, aesthetic concerns such as gray discoloration visible through the thin gingiva, and the risk of corrosion. To overcome these limitations, metal-free implant materials, particularly yttria-niobia-stabilized tetragonal zirconia polycrystals ((Y,Nb)-TZP), have attracted increasing attention. Zirconia has been noted for its advantages, including promising mechanical properties, biocompatibility, aesthetics, and reduced bacterial adhesion. Despite these findings, comparative studies of sandblasted, large-grit, acid-etched (SLA) titanium and (Y,Nb)-TZP are limited. This study aimed to compare the in vitro osteogenic potential and in vivo osseointegration of sandblasted (Y,Nb)-TZP implants with those of conventional SLA titanium implants using 3-dimensional evaluation. (Y,Nb)-TZP implants demonstrated comparable in vitro and in vivo results to SLA titanium, despite significantly lower surface roughness. Early cell attachment and spreading were observed on (Y,Nb)-TZP, whereas alkaline phosphatase activity and late-stage osteogenic gene expression increased over time in both groups without intergroup differences. In in vivo experiments, no significant between-group differences were observed in bone-to-implant contact, bone area, and dynamic bone remodeling indices. Three-dimensional-based analysis revealed similar overall bone remodeling volumes but distinct spatial distributions of newly formed bone around the implant threads, providing additional insights into the subcortical peri-implant bone area. In conclusion, sandblasted (Y,Nb)-TZP implants exhibited osteogenic potential and osseointegration comparable to those of SLA titanium implants, supporting the potential clinical applicability of (Y,Nb)-TZP as an alternative implant material. 2026-06-01T00:00:00Z https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/218196 Title: A Tooth-Saving Alternative to Implant Therapy: Guided Tissue Regeneration with Apicoectomy in the Maxillary Anterior Region Authors: 한지영 2026-05-22T00:00:00Z https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/217931 Title: 의사를 위한 치의학 Authors: 한지영 2026-04-01T00:00:00Z